open access

Vol 61, No 4 (2002)
ORIGINAL ARTICLES
Published online: 2002-08-29
Submitted: 2012-02-06
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Divergent effects of quinolinic aminoxyls on mitochondrial ultrastructure and localisation in osteosarcoma 143 B cells

Jan Heryk Spodnik, Jakub Kędzior, Aleksandra Gil, Michał Woźniak, Takashi Wakabayashi, Giancarlo Falcioni, Lucedio Greci
Folia Morphol 2002;61(4):261-264.

open access

Vol 61, No 4 (2002)
ORIGINAL ARTICLES
Published online: 2002-08-29
Submitted: 2012-02-06

Abstract

In the present study we have shown that quinolinic aromatic aminoxyls are very efficient in protecting lipids of endoplasmic reticulum membranes against hydroperoxide- induced oxidation. The efficacy of these aminoxyls as protectors of lipids was much higher than the water-soluble 4-OH-TEMPO. We have also shown that QAL causes distinct changes of the morphology of mitochondria: from filamentous to granular enlarged structure via the folding of the former. QAL induces also perinuclear clustering of mitochondria. C-QAL as well as 4-OH-TEMPO treated cells revealed filamentous and scattered pattern of mitochondria. Antioxidant activity of QAL as well as morphological changes of mitochondrial raise the possibility that this drug can affect cell physiology via changes of mitochondrial function.

Abstract

In the present study we have shown that quinolinic aromatic aminoxyls are very efficient in protecting lipids of endoplasmic reticulum membranes against hydroperoxide- induced oxidation. The efficacy of these aminoxyls as protectors of lipids was much higher than the water-soluble 4-OH-TEMPO. We have also shown that QAL causes distinct changes of the morphology of mitochondria: from filamentous to granular enlarged structure via the folding of the former. QAL induces also perinuclear clustering of mitochondria. C-QAL as well as 4-OH-TEMPO treated cells revealed filamentous and scattered pattern of mitochondria. Antioxidant activity of QAL as well as morphological changes of mitochondrial raise the possibility that this drug can affect cell physiology via changes of mitochondrial function.
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Keywords

QAL; C-QAL; 4-OH-TEMPO; oxidative stress; mitochondrial ultrastructure

About this article
Title

Divergent effects of quinolinic aminoxyls on mitochondrial ultrastructure and localisation in osteosarcoma 143 B cells

Journal

Folia Morphologica

Issue

Vol 61, No 4 (2002)

Pages

261-264

Published online

2002-08-29

Bibliographic record

Folia Morphol 2002;61(4):261-264.

Keywords

QAL
C-QAL
4-OH-TEMPO
oxidative stress
mitochondrial ultrastructure

Authors

Jan Heryk Spodnik
Jakub Kędzior
Aleksandra Gil
Michał Woźniak
Takashi Wakabayashi
Giancarlo Falcioni
Lucedio Greci

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