Vol 61, No 4 (2002)
Original article
Published online: 2002-08-29
Divergent effects of quinolinic aminoxyls on mitochondrial ultrastructure and localisation in osteosarcoma 143 B cells
Folia Morphol 2002;61(4):261-264.
Abstract
In the present study we have shown that quinolinic aromatic aminoxyls are very
efficient in protecting lipids of endoplasmic reticulum membranes against hydroperoxide-
induced oxidation. The efficacy of these aminoxyls as protectors of lipids
was much higher than the water-soluble 4-OH-TEMPO. We have also shown that
QAL causes distinct changes of the morphology of mitochondria: from filamentous
to granular enlarged structure via the folding of the former. QAL induces also
perinuclear clustering of mitochondria. C-QAL as well as 4-OH-TEMPO treated
cells revealed filamentous and scattered pattern of mitochondria. Antioxidant activity
of QAL as well as morphological changes of mitochondrial raise the possibility
that this drug can affect cell physiology via changes of mitochondrial function.
Keywords: QALC-QAL4-OH-TEMPOoxidative stressmitochondrial ultrastructure