open access

Vol 61, No 4 (2002)
ORIGINAL ARTICLES
Published online: 2002-08-29
Submitted: 2012-02-06
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Co-existence of apoptotic and necrotic features within one single cell as a result of menadione treatment

Marcin Kamiński, Mariusz Karbowski, Yu Miyazaki, Jakub Kędzior, Jan Henryk Spodnik, Aleksandra Gil, Michał Woźniak, Takashi Wakabayashi
Folia Morphol 2002;61(4):217-220.

open access

Vol 61, No 4 (2002)
ORIGINAL ARTICLES
Published online: 2002-08-29
Submitted: 2012-02-06

Abstract

In the present study we examined the effects of menadione, a redox cycling agent, on structural changes of human osteosarcoma line 143B cells. It has been previously reported that menadione can cause necrotic or apoptotic cell death in a concentration- depending manner. In our experimental model, cells were treated with 100 μM menadione for 24 hours. Using electron microscopy technique cells carrying three kinds of morphological changes were detected: necrotic cells, apoptotic cells and those demonstrating a co-existence of apoptotic and necrotic features in one single cell.

Abstract

In the present study we examined the effects of menadione, a redox cycling agent, on structural changes of human osteosarcoma line 143B cells. It has been previously reported that menadione can cause necrotic or apoptotic cell death in a concentration- depending manner. In our experimental model, cells were treated with 100 μM menadione for 24 hours. Using electron microscopy technique cells carrying three kinds of morphological changes were detected: necrotic cells, apoptotic cells and those demonstrating a co-existence of apoptotic and necrotic features in one single cell.
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Keywords

menadione; apoptosis; necrosis; single cell; electron microscopy

About this article
Title

Co-existence of apoptotic and necrotic features within one single cell as a result of menadione treatment

Journal

Folia Morphologica

Issue

Vol 61, No 4 (2002)

Pages

217-220

Published online

2002-08-29

Bibliographic record

Folia Morphol 2002;61(4):217-220.

Keywords

menadione
apoptosis
necrosis
single cell
electron microscopy

Authors

Marcin Kamiński
Mariusz Karbowski
Yu Miyazaki
Jakub Kędzior
Jan Henryk Spodnik
Aleksandra Gil
Michał Woźniak
Takashi Wakabayashi

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