open access

Vol 61, No 4 (2002)
ORIGINAL ARTICLES
Published online: 2002-08-29
Submitted: 2012-02-06
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Immunocytochemical evidence for growth hormone-releasing hormone in the tanycytes of the median eminence of the rat

Jose Carretero, Deborah Burks, Manuel Rubio, Enrique Blanco, Julio J. Herrero, Pilar Bodego, Juan A. Juanes, Elena Hernández, Jose M. Riesco
Folia Morphol 2002;61(4):209-216.

open access

Vol 61, No 4 (2002)
ORIGINAL ARTICLES
Published online: 2002-08-29
Submitted: 2012-02-06

Abstract

The current study was performed to analyse the potential existence and structure of a GHRH-transporting tuberoinfundibular system in the rat median eminence. The immunocytochemical analysis using anti-GHRH revealed an intense immunoreaction in the ependimary cells, tanycytes, at the level of the floor of the infundibular recess forming part of the median eminence. The basal processes of these cells course towards the external layer of the median eminence and reach the growth hormone-releasing hormone (GHRH) fibres of the tuberoinfundibular tract and this reaction was increased after intraventricular treatment with colchicine. Thus, these observations suggest the existence of a second or alternative cerebrospinal fluid-mediated route of GHRH transport to the median eminence and implicate the involvement of tanycytes in the regulation of this novel transport system.

Abstract

The current study was performed to analyse the potential existence and structure of a GHRH-transporting tuberoinfundibular system in the rat median eminence. The immunocytochemical analysis using anti-GHRH revealed an intense immunoreaction in the ependimary cells, tanycytes, at the level of the floor of the infundibular recess forming part of the median eminence. The basal processes of these cells course towards the external layer of the median eminence and reach the growth hormone-releasing hormone (GHRH) fibres of the tuberoinfundibular tract and this reaction was increased after intraventricular treatment with colchicine. Thus, these observations suggest the existence of a second or alternative cerebrospinal fluid-mediated route of GHRH transport to the median eminence and implicate the involvement of tanycytes in the regulation of this novel transport system.
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Keywords

hypothalamus; neuropeptides; ependimary cells; immunocytochemistry; colchicine

About this article
Title

Immunocytochemical evidence for growth hormone-releasing hormone in the tanycytes of the median eminence of the rat

Journal

Folia Morphologica

Issue

Vol 61, No 4 (2002)

Pages

209-216

Published online

2002-08-29

Bibliographic record

Folia Morphol 2002;61(4):209-216.

Keywords

hypothalamus
neuropeptides
ependimary cells
immunocytochemistry
colchicine

Authors

Jose Carretero
Deborah Burks
Manuel Rubio
Enrique Blanco
Julio J. Herrero
Pilar Bodego
Juan A. Juanes
Elena Hernández
Jose M. Riesco

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