open access

Vol 62, No 4 (2003)
Short Communications
Published online: 2003-09-05
Submitted: 2012-02-06
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Activity of the thyroid parafollicular (C) cells in simple and hyperactive nodular goitre treated surgically - preliminary investigations

Jacek Dadan, Robert Ł. Zbucki, Bogusław Sawicki, Maria M. Winnicka, Zbigniew Puchalski
Folia Morphol 2003;62(4):443-445.

open access

Vol 62, No 4 (2003)
Short Communications
Published online: 2003-09-05
Submitted: 2012-02-06

Abstract

The aim of this study was to evaluate the significance of measuring calcitonin (CT) plasma concentrations in patients with simple and hyperthyroid goitre treated surgically. Eighty four patients who underwent operations during the years 2000-2002 were analysed. Plasma concentrations of CT were determined by commercially available radioimmunoassay on the day of hospitalisation. Elevated concentrations of CT were found in 8 patients: in 5 out of 26 (19.2%) and in 3 out of 33 (9.0%) patients with Graves’ disease and with multinodular goitre, respectively. No major differences in concentrations of CT were observed in patients with simple goitre. Postoperative morphological analysis of pathologically changed hyperactive thyroids showed the presence of enlarged C cells distributed either in small groups or even singly with weakening immunohistochemical reaction for CT. These observations may point to the possibility of a relationship between the functional state of the thyroid gland and the activity of C cells.

Abstract

The aim of this study was to evaluate the significance of measuring calcitonin (CT) plasma concentrations in patients with simple and hyperthyroid goitre treated surgically. Eighty four patients who underwent operations during the years 2000-2002 were analysed. Plasma concentrations of CT were determined by commercially available radioimmunoassay on the day of hospitalisation. Elevated concentrations of CT were found in 8 patients: in 5 out of 26 (19.2%) and in 3 out of 33 (9.0%) patients with Graves’ disease and with multinodular goitre, respectively. No major differences in concentrations of CT were observed in patients with simple goitre. Postoperative morphological analysis of pathologically changed hyperactive thyroids showed the presence of enlarged C cells distributed either in small groups or even singly with weakening immunohistochemical reaction for CT. These observations may point to the possibility of a relationship between the functional state of the thyroid gland and the activity of C cells.
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Keywords

C cells; calcitonin; hyperthyroidism; nodular goitre

About this article
Title

Activity of the thyroid parafollicular (C) cells in simple and hyperactive nodular goitre treated surgically - preliminary investigations

Journal

Folia Morphologica

Issue

Vol 62, No 4 (2003)

Pages

443-445

Published online

2003-09-05

Bibliographic record

Folia Morphol 2003;62(4):443-445.

Keywords

C cells
calcitonin
hyperthyroidism
nodular goitre

Authors

Jacek Dadan
Robert Ł. Zbucki
Bogusław Sawicki
Maria M. Winnicka
Zbigniew Puchalski

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