open access

Vol 63, No 1 (2004)
Short Communications
Published online: 2003-12-03
Submitted: 2012-02-06
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Evaluation of apoptosis, proliferation intensity and metallothionein (MT) expression in comparison with selected clinicopathological variables in primary adenocarcinomas of the large intestine

Małgorzata Dumańska, Piotr Dzięgiel, Mirosław Sopel, Andrzej Wojnar, Maciej Zabel
Folia Morphol 2004;63(1):107-110.

open access

Vol 63, No 1 (2004)
Short Communications
Published online: 2003-12-03
Submitted: 2012-02-06

Abstract

Tumour growth and expansion are the result of proliferative activity and the capacity to eliminate cells by apoptosis and/or necrosis. The present study was aimed at comparing the apoptosis and proliferation intensity in cells of adenocarcinomas of the large intestine with the expression of metallothionein (MT), the grade of the tumour and the depth to which the tumour infiltrated the intestinal wall. The TUNEL technique and immunocytochemical reactions (expression of caspase-3, Ki-67, MT) were used to detect apoptosis. The results demonstrated augmented levels of all the variables examined, positively correlated with grade of malignancy, G, and with the depth of intestinal wall infiltration by the tumour cells. The testing of apoptosis, proliferation and MT expression may prove useful in the appraisal of the growth and progression of primary adenocarcinomas in the large intestine.

Abstract

Tumour growth and expansion are the result of proliferative activity and the capacity to eliminate cells by apoptosis and/or necrosis. The present study was aimed at comparing the apoptosis and proliferation intensity in cells of adenocarcinomas of the large intestine with the expression of metallothionein (MT), the grade of the tumour and the depth to which the tumour infiltrated the intestinal wall. The TUNEL technique and immunocytochemical reactions (expression of caspase-3, Ki-67, MT) were used to detect apoptosis. The results demonstrated augmented levels of all the variables examined, positively correlated with grade of malignancy, G, and with the depth of intestinal wall infiltration by the tumour cells. The testing of apoptosis, proliferation and MT expression may prove useful in the appraisal of the growth and progression of primary adenocarcinomas in the large intestine.
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Keywords

large intestine adenocarcinoma; apoptosis; metallothionein; Ki-67 antigen

About this article
Title

Evaluation of apoptosis, proliferation intensity and metallothionein (MT) expression in comparison with selected clinicopathological variables in primary adenocarcinomas of the large intestine

Journal

Folia Morphologica

Issue

Vol 63, No 1 (2004)

Pages

107-110

Published online

2003-12-03

Bibliographic record

Folia Morphol 2004;63(1):107-110.

Keywords

large intestine adenocarcinoma
apoptosis
metallothionein
Ki-67 antigen

Authors

Małgorzata Dumańska
Piotr Dzięgiel
Mirosław Sopel
Andrzej Wojnar
Maciej Zabel

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