Vol 63, No 1 (2004)
Short communication
Published online: 2003-12-03
Evaluation of apoptosis, proliferation intensity and metallothionein (MT) expression in comparison with selected clinicopathological variables in primary adenocarcinomas of the large intestine
Folia Morphol 2004;63(1):107-110.
Abstract
Tumour growth and expansion are the result of proliferative activity and the
capacity to eliminate cells by apoptosis and/or necrosis. The present study was
aimed at comparing the apoptosis and proliferation intensity in cells of adenocarcinomas
of the large intestine with the expression of metallothionein (MT),
the grade of the tumour and the depth to which the tumour infiltrated the
intestinal wall. The TUNEL technique and immunocytochemical reactions (expression
of caspase-3, Ki-67, MT) were used to detect apoptosis. The results
demonstrated augmented levels of all the variables examined, positively correlated
with grade of malignancy, G, and with the depth of intestinal wall infiltration
by the tumour cells. The testing of apoptosis, proliferation and MT expression
may prove useful in the appraisal of the growth and progression of primary
adenocarcinomas in the large intestine.
Keywords: large intestine adenocarcinomaapoptosismetallothioneinKi-67 antigen
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