Multimedialna platforma wiedzy medycznej Internetowa Księgarnia Medyczna Kalendarium Konferencji
Folia Morphologica
MENU
Shortcuts Submit an article Author Guidelines (new) Ahead Of Print Reviewers 2023

open access

Vol 63, No 1 (2004)
Short communication
Submitted: 2012-02-06
Published online: 2003-12-03
View PDF Download PDF file
Get Citation

The distribution and influence of calcitonin gene-related peptide (CGRP) on the perfusion pressure in the isolated ovarian artery in the pig

Włodzimierz Markiewicz, Jerzy J. Jaroszewski, Beata Barszczewska, Tomasz Maślanka, Mariusz Majewski
Folia Morphol 2004;63(1):99-101.

open access

Vol 63, No 1 (2004)
SHORT COMMUNICATIONS
Submitted: 2012-02-06
Published online: 2003-12-03

Abstract

A moderate number of delicate CGRP-immunoreactive (CGRP-IR) varicose nerve terminals were found at the adventitia-media border of the sexually mature porcine ovarian artery by means of a routine single immunolabelling technique. Additionally, a pharmacological analysis was performed of the function fulfilled by α-CGRP and its C-terminal fragment (Tyr27) α-CGRP(27-37) in the porcine isolated ovarian artery, collected on days 8–13 of the oestrous cycle. It was shown that α-CGRP (10-8 M) caused a decrease in the perfusion pressure of the porcine isolated ovarian artery of 16% (p < 0.05), while (Tyr27) α-CGRP(27-37), added at the same concentration, reduced perfusion pressure by 13% (p > 0.05). Thus, we concluded that α-CGRP released from perivascular terminals may cause relaxation of the ovarian artery and, furthermore, that the potency of this action is dependent on the length of the chain of this peptide produced during the deactivation of the molecule by tissue proteases.

Abstract

A moderate number of delicate CGRP-immunoreactive (CGRP-IR) varicose nerve terminals were found at the adventitia-media border of the sexually mature porcine ovarian artery by means of a routine single immunolabelling technique. Additionally, a pharmacological analysis was performed of the function fulfilled by α-CGRP and its C-terminal fragment (Tyr27) α-CGRP(27-37) in the porcine isolated ovarian artery, collected on days 8–13 of the oestrous cycle. It was shown that α-CGRP (10-8 M) caused a decrease in the perfusion pressure of the porcine isolated ovarian artery of 16% (p < 0.05), while (Tyr27) α-CGRP(27-37), added at the same concentration, reduced perfusion pressure by 13% (p > 0.05). Thus, we concluded that α-CGRP released from perivascular terminals may cause relaxation of the ovarian artery and, furthermore, that the potency of this action is dependent on the length of the chain of this peptide produced during the deactivation of the molecule by tissue proteases.

Full Text:

View PDF Download PDF file
Get Citation

Keywords

alpha-CGRP; (Tyr27)alpha-CGRP(27-37); ovarian artery; perfusion

About this article
Title

The distribution and influence of calcitonin gene-related peptide (CGRP) on the perfusion pressure in the isolated ovarian artery in the pig

Journal

Folia Morphologica

Issue

Vol 63, No 1 (2004)

Article type

Short communication

Pages

99-101

Published online

2003-12-03

Page views

550

Article views/downloads

1069

Bibliographic record

Folia Morphol 2004;63(1):99-101.

Keywords

alpha-CGRP
(Tyr27)alpha-CGRP(27-37)
ovarian artery
perfusion

Authors

Włodzimierz Markiewicz
Jerzy J. Jaroszewski
Beata Barszczewska
Tomasz Maślanka
Mariusz Majewski

Regulations

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By VM Media Group sp. z o.o., Grupa Via Medica, Świętokrzyska 73, 80–180 Gdańsk, Poland

tel.: +48 58 320 94 94, faks: +48 58 320 94 60, e-mail: viamedica@viamedica.pl