Vol 63, No 1 (2004)
Short communication
Published online: 2003-12-03

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Dactinomycin-induced veno-occlusive disease in rats. The hepatoprotective action of amifostine. Evaluation in a light and electron microscope

Halina Borowska, Ewa Arciszewska, Piotr Czauderna, Bogusław Sawicki
Folia Morphol 2004;63(1):91-93.


The purpose of the study was to draw upan experimental model of hepatic veno-occlusive disease (VOD) induced by dactinomycin (ACT) and to investigate the possible hepatoprotective effects of Ethyol (amifostine). Pathological changes corresponding to a VOD picture of varying intensification were found in the liver samples obtained from all the rats receiving ACT. Amifostine appears to act protectively to liver changes caused by dactinomycin.

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