Vol 63, No 1 (2004)
Short communication
Published online: 2003-12-03
Dactinomycin-induced veno-occlusive disease in rats. The hepatoprotective action of amifostine. Evaluation in a light and electron microscope
Folia Morphol 2004;63(1):91-93.
Abstract
The purpose of the study was to draw upan experimental model of hepatic
veno-occlusive disease (VOD) induced by dactinomycin (ACT) and to investigate
the possible hepatoprotective effects of Ethyol (amifostine). Pathological changes
corresponding to a VOD picture of varying intensification were found in the
liver samples obtained from all the rats receiving ACT. Amifostine appears to act
protectively to liver changes caused by dactinomycin.
Keywords: veno-occlusive liver disease (VOD)ethyol (amifostine)dactinomycin (ACT)
