open access

Vol 63, No 1 (2004)
Short Communications
Published online: 2003-12-03
Submitted: 2012-02-06
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Dactinomycin-induced veno-occlusive disease in rats. The hepatoprotective action of amifostine. Evaluation in a light and electron microscope

Halina Borowska, Ewa Arciszewska, Piotr Czauderna, Bogusław Sawicki
Folia Morphol 2004;63(1):91-93.

open access

Vol 63, No 1 (2004)
Short Communications
Published online: 2003-12-03
Submitted: 2012-02-06

Abstract

The purpose of the study was to draw upan experimental model of hepatic veno-occlusive disease (VOD) induced by dactinomycin (ACT) and to investigate the possible hepatoprotective effects of Ethyol (amifostine). Pathological changes corresponding to a VOD picture of varying intensification were found in the liver samples obtained from all the rats receiving ACT. Amifostine appears to act protectively to liver changes caused by dactinomycin.

Abstract

The purpose of the study was to draw upan experimental model of hepatic veno-occlusive disease (VOD) induced by dactinomycin (ACT) and to investigate the possible hepatoprotective effects of Ethyol (amifostine). Pathological changes corresponding to a VOD picture of varying intensification were found in the liver samples obtained from all the rats receiving ACT. Amifostine appears to act protectively to liver changes caused by dactinomycin.
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Keywords

veno-occlusive liver disease (VOD); ethyol (amifostine); dactinomycin (ACT)

About this article
Title

Dactinomycin-induced veno-occlusive disease in rats. The hepatoprotective action of amifostine. Evaluation in a light and electron microscope

Journal

Folia Morphologica

Issue

Vol 63, No 1 (2004)

Pages

91-93

Published online

2003-12-03

Bibliographic record

Folia Morphol 2004;63(1):91-93.

Keywords

veno-occlusive liver disease (VOD)
ethyol (amifostine)
dactinomycin (ACT)

Authors

Halina Borowska
Ewa Arciszewska
Piotr Czauderna
Bogusław Sawicki

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