open access

Vol 63, No 1 (2004)
SHORT COMMUNICATIONS
Published online: 2003-12-03
Submitted: 2012-02-06
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The morphological and histochemical neurosecretory magnocellular system in the rat after administration of chlorpromazine

Ewa Arciszewska, Halina Borowska, Bogusław Sawicki
Folia Morphol 2004;63(1):83-85.

open access

Vol 63, No 1 (2004)
SHORT COMMUNICATIONS
Published online: 2003-12-03
Submitted: 2012-02-06

Abstract

The effect of chlorpromazine (CPZ) on the neurosecretory action of the hypothalamo- hypophyseal system was investigated in 72 male rats. The experimental animals received CPZ in a dose of 0.4 mg, 4.0 mg and 20.0 mg/kg b.w. for 30 days. The rats were sacrificed by decapitation at 24 h and 7 days after the last dose of the drug. The neurosecretory material was stained with paraldehyde fuchsin in the supraoptic nucleus, paraventricular nucleus, eminentia mediana and neurohypophysis, the tigroid was stained with toluidine blue and the acid phosphatase activity was evaluated histoenzymatically. It was found that CPZ reduced the content of the neurosecretory material after 24 h, while an increase was observed 7 days after the last drug administration.

Abstract

The effect of chlorpromazine (CPZ) on the neurosecretory action of the hypothalamo- hypophyseal system was investigated in 72 male rats. The experimental animals received CPZ in a dose of 0.4 mg, 4.0 mg and 20.0 mg/kg b.w. for 30 days. The rats were sacrificed by decapitation at 24 h and 7 days after the last dose of the drug. The neurosecretory material was stained with paraldehyde fuchsin in the supraoptic nucleus, paraventricular nucleus, eminentia mediana and neurohypophysis, the tigroid was stained with toluidine blue and the acid phosphatase activity was evaluated histoenzymatically. It was found that CPZ reduced the content of the neurosecretory material after 24 h, while an increase was observed 7 days after the last drug administration.
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Keywords

magnocellular neurosecretory system; chlorpromazine; rat; acid phosphatase; Gomori - positive neurosecretory material

About this article
Title

The morphological and histochemical neurosecretory magnocellular system in the rat after administration of chlorpromazine

Journal

Folia Morphologica

Issue

Vol 63, No 1 (2004)

Pages

83-85

Published online

2003-12-03

Bibliographic record

Folia Morphol 2004;63(1):83-85.

Keywords

magnocellular neurosecretory system
chlorpromazine
rat
acid phosphatase
Gomori - positive neurosecretory material

Authors

Ewa Arciszewska
Halina Borowska
Bogusław Sawicki

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