Vol 63, No 1 (2004)
Short communication
Submitted: 2012-02-06
Published online: 2003-12-03
The influence of the vascularisation of the follicular thyroid nodules on the proliferative activity of the follicular cells
Urszula M. Łebkowska, Janusz Dzięcioł, Dorota Lemancewicz, Wanda Bogusłowicz, Andrzej Lewszuk
Folia Morphol 2004;63(1):79-81.
Vol 63, No 1 (2004)
SHORT COMMUNICATIONS
Submitted: 2012-02-06
Published online: 2003-12-03
Abstract
The enlargement of the thyroid is, in general, benign in origin and due to nodular
goitre. Follicular cellular proliferation of thyroid nodules has been increasingly
observed recently. With fine needle aspiration biopsy (FNAB) this is classified
as a follicular tumour. These lesions present various patterns of vascularisation
in ultrasound examination. The aim of the study was to establish the relation
between follicular nodule vascularisation and the proliferative activity of various
types of follicular cell. According to the manner of proliferation, patients were
divided into groups as follows: (I) patients with hyperplastic nodules (46 cases),
(II) patients with follicular adenoma (42 cases), and (III) patients with follicular
cancer (9 cases). In each case B-mode sonography, Power Doppler, sonographically
guided FNAB (S-FNAB), morphological examination and morphometry were
performed. The proliferative activity was detected with immunohistochemical
methods (PCNA, Ki 67 and MPM2) to determine the so-called “proliferative index”.
The study revealed increased proliferative activity in tumours of malignant
origin and increased vascularisation in coexistence with increased proliferation
of the follicular cells. As assessed by Power Doppler, an increased flow pattern
in the centre of the nodules correlates with increased proliferative activity. The
results suggest that Power Doppler examination could be helpful in selecting
nodules for FNAB, especially in multinodular goitre.
Abstract
The enlargement of the thyroid is, in general, benign in origin and due to nodular
goitre. Follicular cellular proliferation of thyroid nodules has been increasingly
observed recently. With fine needle aspiration biopsy (FNAB) this is classified
as a follicular tumour. These lesions present various patterns of vascularisation
in ultrasound examination. The aim of the study was to establish the relation
between follicular nodule vascularisation and the proliferative activity of various
types of follicular cell. According to the manner of proliferation, patients were
divided into groups as follows: (I) patients with hyperplastic nodules (46 cases),
(II) patients with follicular adenoma (42 cases), and (III) patients with follicular
cancer (9 cases). In each case B-mode sonography, Power Doppler, sonographically
guided FNAB (S-FNAB), morphological examination and morphometry were
performed. The proliferative activity was detected with immunohistochemical
methods (PCNA, Ki 67 and MPM2) to determine the so-called “proliferative index”.
The study revealed increased proliferative activity in tumours of malignant
origin and increased vascularisation in coexistence with increased proliferation
of the follicular cells. As assessed by Power Doppler, an increased flow pattern
in the centre of the nodules correlates with increased proliferative activity. The
results suggest that Power Doppler examination could be helpful in selecting
nodules for FNAB, especially in multinodular goitre.
Keywords
thyroid; follicular tumour; Power Doppler; vascularisation; proliferation
Title
The influence of the vascularisation of the follicular thyroid nodules on the proliferative activity of the follicular cells
Journal
Folia Morphologica
Issue
Vol 63, No 1 (2004)
Article type
Short communication
Pages
79-81
Published online
2003-12-03
Page views
598
Article views/downloads
1248
Bibliographic record
Folia Morphol 2004;63(1):79-81.
Keywords
thyroid
follicular tumour
Power Doppler
vascularisation
proliferation
Authors
Urszula M. Łebkowska
Janusz Dzięcioł
Dorota Lemancewicz
Wanda Bogusłowicz
Andrzej Lewszuk