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Vol 63, No 1 (2004)
ORIGINAL ARTICLES
Published online: 2003-12-03
Submitted: 2012-02-06
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Immunolocalization of CGRP, NPY and PGP 9.5 in guinea pig skin

Hanna Gendek-Kubiak, Bogumił L. Kmieć
Folia Morphol 2004;63(1):115-117.

open access

Vol 63, No 1 (2004)
ORIGINAL ARTICLES
Published online: 2003-12-03
Submitted: 2012-02-06

Abstract

By means of immunoperoxidase and immune-alkaline phosphatase methods the immunoreactivities to neuropeptides: neuropeptide Y (NPY), calcitonin gene related peptide (CGRP) and a pan-neuronal marker, the protein gene product 9.5 (PGP 9.5), were evaluated in guinea pig deep dorsal skin specimens. CGRP immunoreactive (CGRP-IR) and NPY-immunoreactive (NPY-IR) nerve fibres were dispersed in the papillary dermis and sometimes inside the hair roots and among the sebaceous gland cells. Such localized nerve fibres have not so far been described. In the subcutaneous layer nerve trunks were found composed of CGRP-IR and NPY-IR nerve fibres. Some of these indicated vestigial or negative immunoreactivity to PGP 9.5.

Abstract

By means of immunoperoxidase and immune-alkaline phosphatase methods the immunoreactivities to neuropeptides: neuropeptide Y (NPY), calcitonin gene related peptide (CGRP) and a pan-neuronal marker, the protein gene product 9.5 (PGP 9.5), were evaluated in guinea pig deep dorsal skin specimens. CGRP immunoreactive (CGRP-IR) and NPY-immunoreactive (NPY-IR) nerve fibres were dispersed in the papillary dermis and sometimes inside the hair roots and among the sebaceous gland cells. Such localized nerve fibres have not so far been described. In the subcutaneous layer nerve trunks were found composed of CGRP-IR and NPY-IR nerve fibres. Some of these indicated vestigial or negative immunoreactivity to PGP 9.5.

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Keywords

CGRP; NPY; PGP 9.5; guinea pig; skin

About this article
Title

Immunolocalization of CGRP, NPY and PGP 9.5 in guinea pig skin

Journal

Folia Morphologica

Issue

Vol 63, No 1 (2004)

Pages

115-117

Published online

2003-12-03

Bibliographic record

Folia Morphol 2004;63(1):115-117.

Keywords

CGRP
NPY
PGP 9.5
guinea pig
skin

Authors

Hanna Gendek-Kubiak
Bogumił L. Kmieć

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