Vol 63, No 1 (2004)
Original article
Published online: 2003-12-03
Immunolocalization of CGRP, NPY and PGP 9.5 in guinea pig skin
Folia Morphol 2004;63(1):115-117.
Abstract
By means of immunoperoxidase and immune-alkaline phosphatase methods the
immunoreactivities to neuropeptides: neuropeptide Y (NPY), calcitonin gene related
peptide (CGRP) and a pan-neuronal marker, the protein gene product 9.5 (PGP
9.5), were evaluated in guinea pig deep dorsal skin specimens. CGRP immunoreactive
(CGRP-IR) and NPY-immunoreactive (NPY-IR) nerve fibres were dispersed in
the papillary dermis and sometimes inside the hair roots and among the sebaceous
gland cells. Such localized nerve fibres have not so far been described. In the subcutaneous
layer nerve trunks were found composed of CGRP-IR and NPY-IR nerve
fibres. Some of these indicated vestigial or negative immunoreactivity to PGP 9.5.
Keywords: CGRPNPYPGP 9.5guinea pigskin