Vol 63, No 1 (2004)
Original article
Published online: 2003-12-03
The effects of quercetin vs cisplatin on proliferation and the apoptotic process in A549 and SW1271 cell lines in in vitro conditions
Folia Morphol 2004;63(1):103-105.
Abstract
Experience over several years has indicated that chemotherapy, even if widely
used, does not always remain effective in the therapy of lung tumours and, in
addition, is linked to serious side effects. In parallel, some plant polyphenols are
known to exert a proapoptotic action on tumour cells while, in contrast, representing
anti-cancerogenic anti-oxidants in living organisms. Our studies were
aimed at comparing the effects of a polyphenol, quercetin, and cisplatin on cells
of various types of lung cancer in in vitro conditions. In these studies we also
attempted to define the relationship between the dose and the duration of the
activity of the compounds. Cisplatin alone was found to induce only a small
reaction in the cells, while in combination with quercetin its anti-proliferative
and pro-apoptotic effects were amplified, depending upon the type of tumour,
the dose and the duration of the drug’s action.
Keywords: quercetincisplatincell cultureapoptosislung tumours