open access

Vol 63, No 1 (2004)
ORIGINAL ARTICLES
Published online: 2003-12-03
Submitted: 2012-02-06
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The effects of quercetin vs cisplatin on proliferation and the apoptotic process in A549 and SW1271 cell lines in in vitro conditions

Sylwia Borska, Elżbieta Gębarowska, Teresa Wysocka, Małgorzata Drąg-Zalesińska, Maciej Zabel
Folia Morphol 2004;63(1):103-105.

open access

Vol 63, No 1 (2004)
ORIGINAL ARTICLES
Published online: 2003-12-03
Submitted: 2012-02-06

Abstract

Experience over several years has indicated that chemotherapy, even if widely used, does not always remain effective in the therapy of lung tumours and, in addition, is linked to serious side effects. In parallel, some plant polyphenols are known to exert a proapoptotic action on tumour cells while, in contrast, representing anti-cancerogenic anti-oxidants in living organisms. Our studies were aimed at comparing the effects of a polyphenol, quercetin, and cisplatin on cells of various types of lung cancer in in vitro conditions. In these studies we also attempted to define the relationship between the dose and the duration of the activity of the compounds. Cisplatin alone was found to induce only a small reaction in the cells, while in combination with quercetin its anti-proliferative and pro-apoptotic effects were amplified, depending upon the type of tumour, the dose and the duration of the drug’s action.

Abstract

Experience over several years has indicated that chemotherapy, even if widely used, does not always remain effective in the therapy of lung tumours and, in addition, is linked to serious side effects. In parallel, some plant polyphenols are known to exert a proapoptotic action on tumour cells while, in contrast, representing anti-cancerogenic anti-oxidants in living organisms. Our studies were aimed at comparing the effects of a polyphenol, quercetin, and cisplatin on cells of various types of lung cancer in in vitro conditions. In these studies we also attempted to define the relationship between the dose and the duration of the activity of the compounds. Cisplatin alone was found to induce only a small reaction in the cells, while in combination with quercetin its anti-proliferative and pro-apoptotic effects were amplified, depending upon the type of tumour, the dose and the duration of the drug’s action.
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Keywords

quercetin; cisplatin; cell culture; apoptosis; lung tumours

About this article
Title

The effects of quercetin vs cisplatin on proliferation and the apoptotic process in A549 and SW1271 cell lines in in vitro conditions

Journal

Folia Morphologica

Issue

Vol 63, No 1 (2004)

Pages

103-105

Published online

2003-12-03

Bibliographic record

Folia Morphol 2004;63(1):103-105.

Keywords

quercetin
cisplatin
cell culture
apoptosis
lung tumours

Authors

Sylwia Borska
Elżbieta Gębarowska
Teresa Wysocka
Małgorzata Drąg-Zalesińska
Maciej Zabel

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