open access

Vol 63, No 1 (2004)
ORIGINAL ARTICLES
Published online: 2003-12-03
Submitted: 2012-02-06
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The effect of angiogenesis inhibitor TNP-470 on the blood vessels of the lungs, kidneys and livers of treated hamsters

Andrzej Myśliwski, Jolanta Kubasik-Juraniec, Patrycja Koszałka, Ewa Szmit
Folia Morphol 2004;63(1):5-9.

open access

Vol 63, No 1 (2004)
ORIGINAL ARTICLES
Published online: 2003-12-03
Submitted: 2012-02-06

Abstract

The growth of solid tumours and their metastases is dependent on the development of new blood vessels (angiogenesis). Therefore angiogenesis inhibitors are potential antitumour drugs.
In our previous studies it was found that the angiogenesis inhibitor TNP-470 given to transplantable melanoma-bearing hamsters can decrease the rate of the tumour growth, although the survival time of the animals treated was not significantly affected. It was found finally that TNP-470 given in the vicinity of the growing tumour can cause complete remission of the melanoma in hamsters treated in this way. To check what side-effects could be evoked by such treatment, an examination of the morphology of the blood vessels of the lungs, kidneys and livers of the treated animals was carried out. It was found that the angiogenesis inhibitor applied did not cause any changes which could be observed by light and electron microscopes in the structure of the examined blood vessels of the treated animals.

Abstract

The growth of solid tumours and their metastases is dependent on the development of new blood vessels (angiogenesis). Therefore angiogenesis inhibitors are potential antitumour drugs.
In our previous studies it was found that the angiogenesis inhibitor TNP-470 given to transplantable melanoma-bearing hamsters can decrease the rate of the tumour growth, although the survival time of the animals treated was not significantly affected. It was found finally that TNP-470 given in the vicinity of the growing tumour can cause complete remission of the melanoma in hamsters treated in this way. To check what side-effects could be evoked by such treatment, an examination of the morphology of the blood vessels of the lungs, kidneys and livers of the treated animals was carried out. It was found that the angiogenesis inhibitor applied did not cause any changes which could be observed by light and electron microscopes in the structure of the examined blood vessels of the treated animals.
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Keywords

TNP-470; melanoma; hamsters; blood vessels

About this article
Title

The effect of angiogenesis inhibitor TNP-470 on the blood vessels of the lungs, kidneys and livers of treated hamsters

Journal

Folia Morphologica

Issue

Vol 63, No 1 (2004)

Pages

5-9

Published online

2003-12-03

Bibliographic record

Folia Morphol 2004;63(1):5-9.

Keywords

TNP-470
melanoma
hamsters
blood vessels

Authors

Andrzej Myśliwski
Jolanta Kubasik-Juraniec
Patrycja Koszałka
Ewa Szmit

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