open access

Vol 63, No 1 (2004)
REVIEW ARTICLES
Published online: 2003-12-03
Submitted: 2012-02-06
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Cell cycle checkpoints - molecular background

Barbara Grzelakowska-Sztabert
Folia Morphol 2004;63(1):1-3.

open access

Vol 63, No 1 (2004)
REVIEW ARTICLES
Published online: 2003-12-03
Submitted: 2012-02-06

Abstract

Cell cycle checkpoints are the surveillance mechanisms monitoring both the fidelity and accuracy of DNA replication and the segregation of chromosomes. By delaying progression through the cell cycle, checkpoints provide more time for repair before the critical phases of DNA replication and ensure the proper segregation of chromosomes during mitosis. The paper provides basic information about the molecular mechanisms operating in various cell cycle checkpoints activated by DNA damage or disturbances in mitotic spindle assembly.

Abstract

Cell cycle checkpoints are the surveillance mechanisms monitoring both the fidelity and accuracy of DNA replication and the segregation of chromosomes. By delaying progression through the cell cycle, checkpoints provide more time for repair before the critical phases of DNA replication and ensure the proper segregation of chromosomes during mitosis. The paper provides basic information about the molecular mechanisms operating in various cell cycle checkpoints activated by DNA damage or disturbances in mitotic spindle assembly.
Get Citation

Keywords

Cdk kinases; ATM; p53; DNA damage; mitotic spindle

About this article
Title

Cell cycle checkpoints - molecular background

Journal

Folia Morphologica

Issue

Vol 63, No 1 (2004)

Pages

1-3

Published online

2003-12-03

Bibliographic record

Folia Morphol 2004;63(1):1-3.

Keywords

Cdk kinases
ATM
p53
DNA damage
mitotic spindle

Authors

Barbara Grzelakowska-Sztabert

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