open access

Vol 44, No 4 (2006)
ORIGINAL PAPERS
Published online: 2007-01-16
Submitted: 2011-12-19
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Expression of the membrane complement regulatory proteins (CD55 and CD59) in human thymus.

Dariusz Sladowski, Aleksander Wasiutyński, Grzegorz Wilczyński, Iwona Grabska-Liberek, Sandra Coecke, Agnieszka Kinsner, Iwona Kochanowska
Folia Histochem Cytobiol 2006;44(4):263-267.

open access

Vol 44, No 4 (2006)
ORIGINAL PAPERS
Published online: 2007-01-16
Submitted: 2011-12-19

Abstract

CD59 is one of the key molecules involved in cell protection against autologus complement. The fact that complement regulatory proteins are able to prevent hyperacute rejection of organs in pig to primate model, raises the question of possible complement regulatory protein (CRP) involvement in the maturation of immunological system. We report here that in foetal and postnatal human thymus, CD59 and CD55 are primarily located on Hassall's corpuscles and medullary epithelial cells. This localization highly correlates with the expression of CD30L, which is the member of the tumour necrosis factor superfamily. Additionally, TUNEL technique was used to visualize distribution of apoptotic cells in the thymus, which revealed the presence of apoptotic cells closely associated with the Hassall's corpuscles. The observed co-localization of CD59, CD55 and CD30L might suggest an involvement of the complement system in thymic selection in humans.

Abstract

CD59 is one of the key molecules involved in cell protection against autologus complement. The fact that complement regulatory proteins are able to prevent hyperacute rejection of organs in pig to primate model, raises the question of possible complement regulatory protein (CRP) involvement in the maturation of immunological system. We report here that in foetal and postnatal human thymus, CD59 and CD55 are primarily located on Hassall's corpuscles and medullary epithelial cells. This localization highly correlates with the expression of CD30L, which is the member of the tumour necrosis factor superfamily. Additionally, TUNEL technique was used to visualize distribution of apoptotic cells in the thymus, which revealed the presence of apoptotic cells closely associated with the Hassall's corpuscles. The observed co-localization of CD59, CD55 and CD30L might suggest an involvement of the complement system in thymic selection in humans.
Get Citation
About this article
Title

Expression of the membrane complement regulatory proteins (CD55 and CD59) in human thymus.

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 44, No 4 (2006)

Pages

263-267

Published online

2007-01-16

Bibliographic record

Folia Histochem Cytobiol 2006;44(4):263-267.

Authors

Dariusz Sladowski
Aleksander Wasiutyński
Grzegorz Wilczyński
Iwona Grabska-Liberek
Sandra Coecke
Agnieszka Kinsner
Iwona Kochanowska

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