open access

Vol 52, No 1 (2014)
Review paper
Submitted: 2014-01-03
Accepted: 2014-03-10
Published online: 2014-05-07
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Dendritic cells in autoimmune disorders and cancer of the thyroid

Andrzej Lewinski, Przemyslaw Wiktor Sliwka, Mariusz Stasiolek
DOI: 10.5603/FHC.2014.0002
·
Folia Histochem Cytobiol 2014;52(1):18-28.

open access

Vol 52, No 1 (2014)
REVIEW
Submitted: 2014-01-03
Accepted: 2014-03-10
Published online: 2014-05-07

Abstract

Dendritic cells (DCs), considered as one of the crucial immune regulatory populations, are implicated in the immune pathology of various disorders. Also in the thyroid gland, DCs were shown to be involved in early and chronic phases of various types of autoimmunity — including Hashimoto’s thyroiditis and Graves’ disease. In thyroid malignant processes, DCs are suggested as an important element of both tumour defence and tumour immune evasion mechanisms. Recent findings emphasize a crucial role of interactions between particular DC subsets and other regulatory cell populations (e.g. FoxP3+ regulatory T cells) in thyroid pathology. Additionally, an increasing attention has been paid to the control of DC function by thyrometabolic conditions. (Folia Histochemica et Cytobiologica 2014, Vol. 52, No. 1, 18–28)

Abstract

Dendritic cells (DCs), considered as one of the crucial immune regulatory populations, are implicated in the immune pathology of various disorders. Also in the thyroid gland, DCs were shown to be involved in early and chronic phases of various types of autoimmunity — including Hashimoto’s thyroiditis and Graves’ disease. In thyroid malignant processes, DCs are suggested as an important element of both tumour defence and tumour immune evasion mechanisms. Recent findings emphasize a crucial role of interactions between particular DC subsets and other regulatory cell populations (e.g. FoxP3+ regulatory T cells) in thyroid pathology. Additionally, an increasing attention has been paid to the control of DC function by thyrometabolic conditions. (Folia Histochemica et Cytobiologica 2014, Vol. 52, No. 1, 18–28)

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Keywords

dendritic cells; thyroid; thyroid cancer; Hashimoto’s thyroiditis; Graves’ disease; Treg cells; thyroid hormones; TSH

About this article
Title

Dendritic cells in autoimmune disorders and cancer of the thyroid

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 52, No 1 (2014)

Article type

Review paper

Pages

18-28

Published online

2014-05-07

DOI

10.5603/FHC.2014.0002

Bibliographic record

Folia Histochem Cytobiol 2014;52(1):18-28.

Keywords

dendritic cells
thyroid
thyroid cancer
Hashimoto’s thyroiditis
Graves’ disease
Treg cells
thyroid hormones
TSH

Authors

Andrzej Lewinski
Przemyslaw Wiktor Sliwka
Mariusz Stasiolek

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