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Dendritic cells in autoimmune disorders and cancer of the thyroid
open access
Abstract
Dendritic cells (DCs), considered as one of the crucial immune regulatory populations, are implicated in the immune pathology of various disorders. Also in the thyroid gland, DCs were shown to be involved in early and chronic phases of various types of autoimmunity — including Hashimoto’s thyroiditis and Graves’ disease. In thyroid malignant processes, DCs are suggested as an important element of both tumour defence and tumour immune evasion mechanisms. Recent findings emphasize a crucial role of interactions between particular DC subsets and other regulatory cell populations (e.g. FoxP3+ regulatory T cells) in thyroid pathology. Additionally, an increasing attention has been paid to the control of DC function by thyrometabolic conditions. (Folia Histochemica et Cytobiologica 2014, Vol. 52, No. 1, 18–28)
Abstract
Dendritic cells (DCs), considered as one of the crucial immune regulatory populations, are implicated in the immune pathology of various disorders. Also in the thyroid gland, DCs were shown to be involved in early and chronic phases of various types of autoimmunity — including Hashimoto’s thyroiditis and Graves’ disease. In thyroid malignant processes, DCs are suggested as an important element of both tumour defence and tumour immune evasion mechanisms. Recent findings emphasize a crucial role of interactions between particular DC subsets and other regulatory cell populations (e.g. FoxP3+ regulatory T cells) in thyroid pathology. Additionally, an increasing attention has been paid to the control of DC function by thyrometabolic conditions. (Folia Histochemica et Cytobiologica 2014, Vol. 52, No. 1, 18–28)
Keywords
dendritic cells; thyroid; thyroid cancer; Hashimoto’s thyroiditis; Graves’ disease; Treg cells; thyroid hormones; TSH
Title
Dendritic cells in autoimmune disorders and cancer of the thyroid
Journal
Folia Histochemica et Cytobiologica
Issue
Article type
Review paper
Pages
18-28
Published online
2014-05-07
Page views
2865
Article views/downloads
3010
DOI
10.5603/FHC.2014.0002
Bibliographic record
Folia Histochem Cytobiol 2014;52(1):18-28.
Keywords
dendritic cells
thyroid
thyroid cancer
Hashimoto’s thyroiditis
Graves’ disease
Treg cells
thyroid hormones
TSH
Authors
Andrzej Lewinski
Przemyslaw Wiktor Sliwka
Mariusz Stasiolek