open access

Vol 18, No 2 (2023)
Review paper
Published online: 2022-09-18
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CA-125: a promising biomarker in heart failure. Summary of the current knowledge

Maria Sawościan1, Małgorzata Lelonek1
DOI: 10.5603/FC.a2022.0052
·
Folia Cardiologica 2023;18(2):65-70.
Affiliations
  1. Department of Noninvasive Cardiology, Chair of Internal Disease and Cardiology, Medical University of Lodz, Łódź, Poland

open access

Vol 18, No 2 (2023)
Review Papers
Published online: 2022-09-18

Abstract

The search for suitable biomarkers for monitoring and treatment of patients with heart failure (HF) is still ongoing. The novel biomarker — carbohydrate antigen 125 (CA-125), used commonly so far in oncology, was proven to be useful in assessing congestion and inflammation in heart failure. Its elevated values are also strongly correlated with impaired right ventricle function. What is more, the increased level of CA-125 correlates positively with HF readmissions and a higher risk of death. Hence, that makes a need to tailor a potential treatment strategy, which was performed in the CHANCE-HF study. Despite the advantages of this biomarker, such as convenient access or significantly low cost of assessments, conducting multicentre and international studies is necessary to implement suitable guidelines.

Abstract

The search for suitable biomarkers for monitoring and treatment of patients with heart failure (HF) is still ongoing. The novel biomarker — carbohydrate antigen 125 (CA-125), used commonly so far in oncology, was proven to be useful in assessing congestion and inflammation in heart failure. Its elevated values are also strongly correlated with impaired right ventricle function. What is more, the increased level of CA-125 correlates positively with HF readmissions and a higher risk of death. Hence, that makes a need to tailor a potential treatment strategy, which was performed in the CHANCE-HF study. Despite the advantages of this biomarker, such as convenient access or significantly low cost of assessments, conducting multicentre and international studies is necessary to implement suitable guidelines.

Get Citation

Keywords

heart failure, acute heart failure, echocardiography, biomarkers, clinical practice

About this article
Title

CA-125: a promising biomarker in heart failure. Summary of the current knowledge

Journal

Folia Cardiologica

Issue

Vol 18, No 2 (2023)

Article type

Review paper

Pages

65-70

Published online

2022-09-18

Page views

701

Article views/downloads

213

DOI

10.5603/FC.a2022.0052

Bibliographic record

Folia Cardiologica 2023;18(2):65-70.

Keywords

heart failure
acute heart failure
echocardiography
biomarkers
clinical practice

Authors

Maria Sawościan
Małgorzata Lelonek

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