open access

Vol 11, No 5 (2016)
Research paper
Published online: 2016-09-13
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Factors influencing troponin T concentration in patients with obstructive sleep apnea syndrome

Marcin Urbańczuk, Paweł Kiciński, Andrzej Dybała, Wojciech Myśliński, Jerzy Mosiewicz, Andrzej Jaroszyński
DOI: 10.5603/FC.a2016.0070
·
Folia Cardiologica 2016;11(5):372-376.

open access

Vol 11, No 5 (2016)
Original Papers
Published online: 2016-09-13

Abstract

Introduction. Obstructive sleep apnea syndrome (OSAS) is strongly associated with adverse cardiovascular outcomes, however the relation between OSAS severity and troponin T (TnT) remain unclear.
Material and methods. Diagnosis and assessment of OSAS severity was based on non-supervised, overnight screening polysomnography (PSG) performed without an adaptation night. The study group consisted of 72 patients diagnosed with OSAS (including 31 with mild, 10 with moderate and 31 patients with severe OSAS), whereas the control group contained 16 individuals. PSG was performed with equipment fulfilling the criteria of type III diagnostic devices according to the American Academy of Sleep Medicine.
Results. Revealed significant differences in troponin T levels between patients with severe OSAS and controls (p = 0.02) as well as in patients with severe and with mild OSAS (p = 0.04). The factors substantially affecting TnT concentrations were found to be apnea–hypopnea index (AHI), apnea index (AI), hypopnea index (HI) and minimum nocturnal saturation.
Conclusions. The relationship between sleep apnea syndrome and the level of serum TnT confirms that OSAS predisposes to myocardial damage in a manner dependent on the severity of sleep apnea. The increase in troponin level is mainly associated with AHI and minimum nocturnal saturation. This suggests that early treatment of OSAS patients may protect against myocardial injury.

Abstract

Introduction. Obstructive sleep apnea syndrome (OSAS) is strongly associated with adverse cardiovascular outcomes, however the relation between OSAS severity and troponin T (TnT) remain unclear.
Material and methods. Diagnosis and assessment of OSAS severity was based on non-supervised, overnight screening polysomnography (PSG) performed without an adaptation night. The study group consisted of 72 patients diagnosed with OSAS (including 31 with mild, 10 with moderate and 31 patients with severe OSAS), whereas the control group contained 16 individuals. PSG was performed with equipment fulfilling the criteria of type III diagnostic devices according to the American Academy of Sleep Medicine.
Results. Revealed significant differences in troponin T levels between patients with severe OSAS and controls (p = 0.02) as well as in patients with severe and with mild OSAS (p = 0.04). The factors substantially affecting TnT concentrations were found to be apnea–hypopnea index (AHI), apnea index (AI), hypopnea index (HI) and minimum nocturnal saturation.
Conclusions. The relationship between sleep apnea syndrome and the level of serum TnT confirms that OSAS predisposes to myocardial damage in a manner dependent on the severity of sleep apnea. The increase in troponin level is mainly associated with AHI and minimum nocturnal saturation. This suggests that early treatment of OSAS patients may protect against myocardial injury.

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Keywords

troponin T, obstructive sleep apnea, apnea–hypopnea index, myocardial injury, polysomnography

About this article
Title

Factors influencing troponin T concentration in patients with obstructive sleep apnea syndrome

Journal

Folia Cardiologica

Issue

Vol 11, No 5 (2016)

Article type

Research paper

Pages

372-376

Published online

2016-09-13

DOI

10.5603/FC.a2016.0070

Bibliographic record

Folia Cardiologica 2016;11(5):372-376.

Keywords

troponin T
obstructive sleep apnea
apnea–hypopnea index
myocardial injury
polysomnography

Authors

Marcin Urbańczuk
Paweł Kiciński
Andrzej Dybała
Wojciech Myśliński
Jerzy Mosiewicz
Andrzej Jaroszyński

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