Clinician’s guide for dapagliflozin use in heart failure with reduced ejection fraction

Abstract

Dapagliflozin belongs to a new class of drugs used for the treatment of heart failure — sodium-glucose cotransporter type 2 inhibitors (SGLT2i). Based on the DAPA-HF study results, dapagliflozin has become the first SGLT2i approved for the treatment of symptomatic chronic heart failure with reduced ejection fraction. The present review summarizes the most important clinical issues related to the treatment with this drug.