open access

Vol 14, No 4 (2019)
Review Papers
Published online: 2019-09-06
Get Citation

Immune system and hypertension

Magdalena Reiwer-Gostomska, Maria Skrzypkowska, Janusz Siebert
DOI: 10.5603/FC.2019.0094
·
Folia Cardiologica 2019;14(4):363-367.

open access

Vol 14, No 4 (2019)
Review Papers
Published online: 2019-09-06

Abstract

Hypertension is a very common disorder. It is a major risk factor of myocardial infarction, heart failure, stroke and renal failure. It is well known that the immune system also contributes to this disease. Numerous investigations have demonstrated that lymphocytes are important participants in the development of hypertension and consequent end-organ damage. They produce different cytokines such as tumor necrosis factor α, interferon γ, and interleukin 6 that lead to the development of hypertension. On the other hand, they are also the source of anti-inflammatory interleukin 10. A better knowledge of immunology would lead to the discovery of new therapeutic interventions and more successful treatment of our patients.

Abstract

Hypertension is a very common disorder. It is a major risk factor of myocardial infarction, heart failure, stroke and renal failure. It is well known that the immune system also contributes to this disease. Numerous investigations have demonstrated that lymphocytes are important participants in the development of hypertension and consequent end-organ damage. They produce different cytokines such as tumor necrosis factor α, interferon γ, and interleukin 6 that lead to the development of hypertension. On the other hand, they are also the source of anti-inflammatory interleukin 10. A better knowledge of immunology would lead to the discovery of new therapeutic interventions and more successful treatment of our patients.

Get Citation

Keywords

hypertension; immune system; lymphocytes;

About this article
Title

Immune system and hypertension

Journal

Folia Cardiologica

Issue

Vol 14, No 4 (2019)

Pages

363-367

Published online

2019-09-06

DOI

10.5603/FC.2019.0094

Bibliographic record

Folia Cardiologica 2019;14(4):363-367.

Keywords

hypertension
immune system
lymphocytes

Authors

Magdalena Reiwer-Gostomska
Maria Skrzypkowska
Janusz Siebert

References (31)
  1. Trzeciak BG, Siebert J, Gutknecht P, et al. Cardiovascular risk factors determined via the Internet in 2 periods of time: 2004-2009 and 2010-2015 in Poland. Int J Occup Med Environ Health. 2017; 30(3): 499–510.
  2. WHITE FN, GROLLMAN A. AUTOIMMUNE FACTORS ASSOCIATED WITH INFARCTION OF THE KIDNEY. Nephron. 1964; 1: 93–102.
  3. Svendsen UG. The role of thymus for the development and prognosis of hypertension and hypertensive vascular disease in mice following renal infarction. Acta Pathol Microbiol Scand A. 1976; 84(3): 235–243.
  4. Ba D, Takeichi N, Kodama T, et al. Restoration of T cell depression and suppression of blood pressure in spontaneously hypertensive rats (SHR) by thymus grafts or thymus extracts. J Immunol. 1982; 128: 1211–1216.
  5. Guzik TJ, Hoch NE, Brown KA, et al. Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction. J Exp Med. 2007; 204(10): 2449–2460.
  6. Crowley SD, Song YS, Lin EE, et al. Lymphocyte responses exacerbate angiotensin II-dependent hypertension. Am J Physiol Regul Integr Comp Physiol. 2010; 298(4): R1089–R1097.
  7. Felten DL, Livnat S, Felten SY, et al. Sympathetic innervation of lymph nodes in mice. Brain Res Bull. 1984; 13(6): 693–699.
  8. Trott DW, Harrison DG. The immune system in hypertension. Adv Physiol Educ. 2014; 38(1): 20–24.
  9. Lob HE, Marvar PJ, Guzik TJ, et al. Induction of hypertension and peripheral inflammation by reduction of extracellular superoxide dismutase in the central nervous system. Hypertension. 2010; 55(2): 277–83, 6p following 283.
  10. Shi P, Diez-Freire C, Jun JY, et al. Brain microglial cytokines in neurogenic hypertension. Hypertension. 2010; 56(2): 297–303.
  11. Lob HE, Vinh A, Li Li, et al. Role of vascular extracellular superoxide dismutase in hypertension. Hypertension. 2011; 58(2): 232–239.
  12. Marvar PJ, Thabet SR, Guzik TJ, et al. Central and peripheral mechanisms of T-lymphocyte activation and vascular inflammation produced by angiotensin II-induced hypertension. Circ Res. 2010; 107(2): 263–270.
  13. Brody M, Fink G, Buggy J, et al. Critical role of the anteroventral third ventricle (AV3V) region in development and maintenance of experimental hypertension. Perspect Nephrol Hypertens. 1979; 6: 76–84.
  14. Nosalski R, McGinnigle E, Siedlinski M, et al. Novel Immune Mechanisms in Hypertension and Cardiovascular Risk. Curr Cardiovasc Risk Rep. 2017; 11(4): 12.
  15. Guzik TJ, Skiba DS, Touyz RM, et al. The role of infiltrating immune cells in dysfunctional adipose tissue. Cardiovasc Res. 2017; 113(9): 1009–1023.
  16. McMaster WG, Kirabo A, Madhur MS, et al. Inflammation, immunity, and hypertensive end-organ damage. Circ Res. 2015; 116(6): 1022–1033.
  17. Gu C, Wu L, Li X. IL-17 family: cytokines, receptors and signaling. Cytokine. 2013; 64(2): 477–485.
  18. Madhur MS, Lob HE, McCann LA, et al. Interleukin 17 promotes angiotensin II-induced hypertension and vascular dysfunction. Hypertension. 2010; 55(2): 500–507.
  19. Wu J, Thabet SR, Kirabo A, et al. Inflammation and mechanical stretch promote aortic stiffening in hypertension through activation of p38 mitogen-activated protein kinase. Circ Res. 2014; 114(4): 616–625.
  20. Ishimitsu T, Uehara Y, Numabe A, et al. Interferon gamma attenuates hypertensive renal injury in salt-sensitive Dahl rats. Hypertension. 1992; 19(6 Pt 2): 804–808.
  21. Markó L, Kvakan H, Park JK, et al. Interferon-γ signaling inhibition ameliorates angiotensin II-induced cardiac damage. Hypertension. 2012; 60(6): 1430–1436.
  22. Ramseyer VD, Garvin JL. Tumor necrosis factor-α: regulation of renal function and blood pressure. Am J Physiol Renal Physiol. 2013; 304(10): F1231–F1242.
  23. Garvin JL, Herrera M, Ortiz PA. Regulation of renal NaCl transport by nitric oxide, endothelin, and ATP: clinical implications. Annu Rev Physiol. 2011; 73: 359–376.
  24. Jose PA, Raj D. Gut microbiota in hypertension. Curr Opin Nephrol Hypertens. 2015; 24(5): 403–409.
  25. Rodriguez-Iturbe B, Pons H, Johnson RJ. Role of the Immune System in Hypertension. Physiol Rev. 2017; 97(3): 1127–1164.
  26. Nakamura Y, Yamamoto N, Sakai K, et al. Antihypertensive effect of sour milk and peptides isolated from it that are inhibitors to angiotensin I-converting enzyme. J Dairy Sci. 1995; 78(6): 1253–1257.
  27. Yang T, Santisteban MM, Rodriguez V, et al. Gut dysbiosis is linked to hypertension. Hypertension. 2015; 65(6): 1331–1340.
  28. Khalesi S, Sun J, Buys N, et al. Effect of probiotics on blood pressure: a systematic review and meta-analysis of randomized, controlled trials. Hypertension. 2014; 64(4): 897–903.
  29. Kassan M, Wecker A, Kadowitz P, et al. CD4+CD25+Foxp3 regulatory T cells and vascular dysfunction in hypertension. J Hypertens. 2013; 31(10): 1939–1943.
  30. Radwan E, Mali V, Haddox S, et al. Treg cells depletion is a mechanism that drives microvascular dysfunction in mice with established hypertension. Biochim Biophys Acta Mol Basis Dis. 2019; 1865(2): 403–412.
  31. Chen S, Agrawal DK. Dysregulation of T cell subsets in the pathogenesis of hypertension. Curr Hypertens Rep. 2015; 17(2): 8.

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

 

Wydawcą serwisu jest  "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl