open access

Vol 12, No 5 (2017)
Evidence-based medicine — What's New?
Published online: 2017-11-22
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Proprotein convertase subtilisin/kexin type 9 (PCSK-9) — new perspective in treatment lipid disorders

Zbigniew Bednarkiewicz, Jarosław D. Kasprzak, Jan Bednarkiewicz
DOI: 10.5603/FC.2017.0100
·
Folia Cardiologica 2017;12(5):528-532.

open access

Vol 12, No 5 (2017)
Evidence-based medicine — What's New?
Published online: 2017-11-22

Abstract

Not available

Abstract

Not available
Get Citation
About this article
Title

Proprotein convertase subtilisin/kexin type 9 (PCSK-9) — new perspective in treatment lipid disorders

Journal

Folia Cardiologica

Issue

Vol 12, No 5 (2017)

Pages

528-532

Published online

2017-11-22

DOI

10.5603/FC.2017.0100

Bibliographic record

Folia Cardiologica 2017;12(5):528-532.

Authors

Zbigniew Bednarkiewicz
Jarosław D. Kasprzak
Jan Bednarkiewicz

References (14)
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  5. Koren MJ, Scott R, Kim JB, et al. Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 as monotherapy in patients with hypercholesterolaemia (MENDEL): a randomised, double-blind, placebo-controlled, phase 2 study. Lancet. 2012; 380(9858): 1995–2006.
  6. Stein EA, Honarpour N, Wasserman SM, et al. Effect of the proprotein convertase subtilisin/kexin 9 monoclonal antibody, AMG 145, in homozygous familial hypercholesterolemia. Circulation. 2013; 128(19): 2113–2120.
  7. Raal F, Scott R, Somaratne R, et al. Low-density lipoprotein cholesterol-lowering effects of AMG 145, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease in patients with heterozygous familial hypercholesterolemia: the Reduction of LDL-C with PCSK9 Inhibition in Heterozygous Familial Hypercholesterolemia Disorder (RUTHERFORD) randomized trial. Circulation. 2012; 126(20): 2408–2417.
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  9. Koren MJ, Roth EM, McKenney JM, et al. Atorvastatin with or without an antibody to PCSK9 in primary hypercholesterolemia. N Engl J Med. 2012; 367(20): 1891–1900.
  10. Robinson JG, Farnier M, Krempf M, et al. ODYSSEY LONG TERM Investigators. Efficacy and safety of alirocumab in reducing lipids and cardiovascular events. N Engl J Med. 2015; 372(16): 1489–1499.
  11. Sabatine MS, Giugliano RP, Wiviott SD, et al. Open-Label Study of Long-Term Evaluation against LDL Cholesterol (OSLER) Investigators. Efficacy and safety of evolocumab in reducing lipids and cardiovascular events. N Engl J Med. 2015; 372(16): 1500–1509.
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  13. Nicholls SJ, Puri R, Anderson T, et al. Effect of Evolocumab on Progression of Coronary Disease in Statin-Treated Patients: The GLAGOV Randomized Clinical Trial. JAMA. 2016; 316(22): 2373–2384.
  14. Giugliano RP, Mach F, Zavitz K, et al. EBBINGHAUS Investigators. Design and rationale of the EBBINGHAUS trial: A phase 3, double-blind, placebo-controlled, multicenter study to assess the effect of evolocumab on cognitive function in patients with clinically evident cardiovascular disease and receiving statin background lipid-lowering therapy-A cognitive study of patients enrolled in the FOURIER trial. Clin Cardiol. 2017; 40(2): 59–65.

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