open access

Vol 11, No 3 (2016)
Research paper
Published online: 2016-07-13
Get Citation

The association of A1166C gene polymorphism of angiotensin receptors with the parameters of central pulse wave in normotensive persons and patients with hypertension

Sergiy Lozinsky
DOI: 10.5603/FC.2016.0028
·
Folia Cardiologica 2016;11(3):180-185.

open access

Vol 11, No 3 (2016)
Original Papers
Published online: 2016-07-13

Abstract

Introduction. Available information about the impact of the polymorphic structure of type 1 angiotensin receptor (ATR1) gene on the central pulse wave is scarce and contradictory. The aim of the study was to establish a possible association of A1166C polymorphism of ATR1 gene with the pulse wave parameters obtained by applanation tonometry.

Material and metods. We examined male and female persons aged 25 to 76 years. They were divided into two groups: the basic consisting of 150 hypertensive patients and the control group presented by 128 individuals with normal blood pressure. In addition to the general clinical exam three-fold measurements of systolic and diastolic blood pressure (systolic blood pressure [SBP] and diastolic blood pressure [DBP], respectively) with the automatic blood pressure monitor Omron M3 were provided mandatory. The structure of the polymorphic receptor gene ATR1 was defined in all participants by polymerase chain reaction on the thermocycler PHC (Techne, UK). Pulse wave analysis was provided with applanation tonometry. For this purpose we used Sphygmocor XCEL equipment (AtCor Medical, Australia).

Results. Analysis of mean SBP and DBP in dependence on ATR1 genotype and existence of arterial hypertension showed that there was a tendency to rise with increasing number of C alleles, but statistical significance of the trend had been confirmed by ANOVA only for SBP in patients with hypertension. Also it was shown a significant difference in central diastolic blood pressure (CDBP) and pulse pressure augmentation (PPA) in hypertensive patients compared with normotensive. It was found a tendency to decrease CDBP and PPA with increasing number of C alleles. The subjects of the control group demonstrated the same trend of PPA as in the group of hypertensive patients.

Conclusion. Thus, we established the association between decrease of PPA and increase of C alleles number in the ATR1 gene.

Abstract

Introduction. Available information about the impact of the polymorphic structure of type 1 angiotensin receptor (ATR1) gene on the central pulse wave is scarce and contradictory. The aim of the study was to establish a possible association of A1166C polymorphism of ATR1 gene with the pulse wave parameters obtained by applanation tonometry.

Material and metods. We examined male and female persons aged 25 to 76 years. They were divided into two groups: the basic consisting of 150 hypertensive patients and the control group presented by 128 individuals with normal blood pressure. In addition to the general clinical exam three-fold measurements of systolic and diastolic blood pressure (systolic blood pressure [SBP] and diastolic blood pressure [DBP], respectively) with the automatic blood pressure monitor Omron M3 were provided mandatory. The structure of the polymorphic receptor gene ATR1 was defined in all participants by polymerase chain reaction on the thermocycler PHC (Techne, UK). Pulse wave analysis was provided with applanation tonometry. For this purpose we used Sphygmocor XCEL equipment (AtCor Medical, Australia).

Results. Analysis of mean SBP and DBP in dependence on ATR1 genotype and existence of arterial hypertension showed that there was a tendency to rise with increasing number of C alleles, but statistical significance of the trend had been confirmed by ANOVA only for SBP in patients with hypertension. Also it was shown a significant difference in central diastolic blood pressure (CDBP) and pulse pressure augmentation (PPA) in hypertensive patients compared with normotensive. It was found a tendency to decrease CDBP and PPA with increasing number of C alleles. The subjects of the control group demonstrated the same trend of PPA as in the group of hypertensive patients.

Conclusion. Thus, we established the association between decrease of PPA and increase of C alleles number in the ATR1 gene.

Get Citation

Keywords

A1166C polymorphism, association, pulse wave analysis, hypertensive and normotensive patients

About this article
Title

The association of A1166C gene polymorphism of angiotensin receptors with the parameters of central pulse wave in normotensive persons and patients with hypertension

Journal

Folia Cardiologica

Issue

Vol 11, No 3 (2016)

Article type

Research paper

Pages

180-185

Published online

2016-07-13

DOI

10.5603/FC.2016.0028

Bibliographic record

Folia Cardiologica 2016;11(3):180-185.

Keywords

A1166C polymorphism
association
pulse wave analysis
hypertensive and normotensive patients

Authors

Sergiy Lozinsky

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

 

Wydawcą serwisu jest  "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl