open access

Vol 10, No 6 (2015)
Review Papers
Published online: 2016-01-11
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LCZ696 breakthrough in the treatment of chronic heart failure with reduced left ventricular ejection fraction

Sebastian Sobczak, Małgorzata Lelonek
DOI: 10.5603/FC.2015.0077
·
Folia Cardiologica 2015;10(6):403-409.

open access

Vol 10, No 6 (2015)
Review Papers
Published online: 2016-01-11

Abstract

Heart failure is a common clinical problem; in developed countries it occurs in 1–2% of the adult population. Despite advances in treatment, outcome the prognosis in this disease remains unfavourable. In the pathophysiology of heart failure with reduced ejection fraction fundamental role play neurohormonal pathways, mainly the activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system, and natriuretic peptides. In the pharmacotherapy of heart failure promising are drugs that modulate the neurohormonal pathways. The paper presents the key results of clinical trials with the new molecule LCZ696, the first angiotensin receptor neprilysin inhibitor (ARNI).

Abstract

Heart failure is a common clinical problem; in developed countries it occurs in 1–2% of the adult population. Despite advances in treatment, outcome the prognosis in this disease remains unfavourable. In the pathophysiology of heart failure with reduced ejection fraction fundamental role play neurohormonal pathways, mainly the activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system, and natriuretic peptides. In the pharmacotherapy of heart failure promising are drugs that modulate the neurohormonal pathways. The paper presents the key results of clinical trials with the new molecule LCZ696, the first angiotensin receptor neprilysin inhibitor (ARNI).

Get Citation

Keywords

heart failure, neurohormonal system modulation, angiotensin receptor II blocker and neprilysin inhibitor, ARNI

About this article
Title

LCZ696 breakthrough in the treatment of chronic heart failure with reduced left ventricular ejection fraction

Journal

Folia Cardiologica

Issue

Vol 10, No 6 (2015)

Pages

403-409

Published online

2016-01-11

DOI

10.5603/FC.2015.0077

Bibliographic record

Folia Cardiologica 2015;10(6):403-409.

Keywords

heart failure
neurohormonal system modulation
angiotensin receptor II blocker and neprilysin inhibitor
ARNI

Authors

Sebastian Sobczak
Małgorzata Lelonek

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