open access

Vol 10, No 4 (2015)
Review Papers
Published online: 2015-08-28
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Genetic aspects of clopidogrel pharmacokinetics and pharmacodynamics

Ewa Laskowska, Aldona Kubica, Jacek Kubica
DOI: 10.5603/FC.2015.0049
·
Folia Cardiologica 2015;10(4):275-282.

open access

Vol 10, No 4 (2015)
Review Papers
Published online: 2015-08-28

Abstract

Clopidogrel is one of drugs used in patients with acute coronary syndromes. Clopidogrel is metabolized to active metabolite, which is an irreversible platelet P2Y12 adenosine diphosphate receptor antagonist. The pharmacokinetic and pharmacodynamic response to clopidogrel varies between individuals. The paper presents a systematic review of studies evaluating the association between genetic factors and clinical efficacy of clopidogrel.

Abstract

Clopidogrel is one of drugs used in patients with acute coronary syndromes. Clopidogrel is metabolized to active metabolite, which is an irreversible platelet P2Y12 adenosine diphosphate receptor antagonist. The pharmacokinetic and pharmacodynamic response to clopidogrel varies between individuals. The paper presents a systematic review of studies evaluating the association between genetic factors and clinical efficacy of clopidogrel.

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Keywords

clopidogrel, platelet aggregation, CYP2C19*2 polymorphism, ABCB1 polymorphism

About this article
Title

Genetic aspects of clopidogrel pharmacokinetics and pharmacodynamics

Journal

Folia Cardiologica

Issue

Vol 10, No 4 (2015)

Pages

275-282

Published online

2015-08-28

DOI

10.5603/FC.2015.0049

Bibliographic record

Folia Cardiologica 2015;10(4):275-282.

Keywords

clopidogrel
platelet aggregation
CYP2C19*2 polymorphism
ABCB1 polymorphism

Authors

Ewa Laskowska
Aldona Kubica
Jacek Kubica

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