Tom 19 (2024): Continuous Publishing
Artykuł przeglądowy
Opublikowany online: 2024-05-02
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Związek procesu zapalnego ze współwystępowaniem depresji i chorób sercowo-naczyniowych oraz możliwości terapeutyczne.
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DOI: 10.5603/fc.99197
Streszczenie
Choroby sercowo-naczyniowe (CVD, cardiovascular diseases) oraz depresja zajmują czołowe miejsca wśród najczęściej występujących chorób w populacji ogólnej. W ostatnim czasie przeprowadzono wiele badań nad zapalną komponentą tych chorób. Nie jest jasny związek przyczynowo-skutkowy odpowiedzialny za tak częste ich współistnienie. Wśród mechanizmówzwiązanych z rozwojem depresji wyodrębnione zostały między innymi zachwianie osi jelita-mózg, zaburzenia aktywności mikrogleju, zwiększone stężenie CRP (C reactive protein), IL-6 (Interleukine 6) i stres oksydacyjny. CVD wiążą się z aktywacją inflamosomu NRLP-3 (NOD-like receptor protein 3), wzrostem stężenia hsCRP (highly sensitive C reactive protein) oraz interleukin: IL-1β, IL-6, IL-18, dysfunkcją osi jelita-mózg i stresem oksydacyjnym. Celem pracy jest ustalenie związku pomiędzy CVD, a depresją w kontekście stanu zapalnego w organizmie (systemic inflammation) oraz przegląd związków wpływających na redukcję lub modulację stanu zapalnego, które potencjalnie mogłyby zostać wykorzystane klinicznie w redukcji ryzyka sercowo-naczyniowego wśród pacjentów z depresją.
Słowa kluczowe: depresjachoroby sercowo-naczyniowezapalenie
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