English Polski
Vol 17, No 1 (2022)
Published online: 2022-02-28

open access

Page views 1980
Article views/downloads 130
Get Citation

Connect on Social Media

Connect on Social Media

Od Redaktora

Beata Wożakowska-Kapłon
Folia Cardiologica 2022;17(1).


Not available

Article available in PDF format

View PDF (Polish) Download PDF file


  1. https://www.ncausa.org/ (Access: 25th, January, 2022).
  2. https://anamsuperlink.blogspot.com/2017/09/secret-billions-of-people-drink-cofee.html ((Access: 25th, January, 2022)).
  3. Surma S, Oparil S. Coffee and arterial hypertension. Curr Hypertens Rep. 2021; 23(7): 38.
  4. Surma S, Kokot F. Influence of chronic coffee consumption on the risk of kidney and other organ diseases. Renal Disease and Transplantation Forum. 2022: in print.
  5. Grosso G, Micek A, Godos J, et al. Coffee consumption and risk of all-cause, cardiovascular, and cancer mortality in smokers and non-smokers: a dose-response meta-analysis. Eur J Epidemiol. 2016; 31(12): 1191–1205.
  6. Lippi G, Sanchis-Gomar F, Cervellin G. Global epidemiology of atrial fibrillation: an increasing epidemic and public health challenge. Int J Stroke. 2021; 16(2): 217–221.
  7. Odutayo A, Wong CX, Hsiao AJ, et al. Atrial fibrillation and risks of cardiovascular disease, renal disease, and death: systematic review and meta-analysis. BMJ. 2016; 354: i4482.
  8. Harrison SL, Fazio-Eynullayeva E, Lane DA, et al. Atrial fibrillation and the risk of 30-day incident thromboembolic events, and mortality in adults ≥ 50 years with COVID-19. J Arrhythm. 2021; 37(1): 231–237.
  9. Romiti GF, Corica B, Lip GYH, et al. Prevalence and impact of atrial fibrillation in hospitalized patients with COVID-19: a systematic review and meta-analysis. J Clin Med. 2021; 10(11).
  10. Burdett P, Lip GYH. Atrial fibrillation in the United Kingdom: predicting costs of an emerging epidemic recognising and forecasting the cost drivers of atrial fibrillation-related costs. Eur Heart J Qual Care Clin Outcomes. 2020: qcaa093.
  11. Gorenek B, Pelliccia A, Benjamin EJ, et al. European Heart Rhythm Association (EHRA)/European Association of Cardiovascular Prevention and Rehabilitation (EACPR) position paper on how to prevent atrial fibrillation endorsed by the Heart Rhythm Society (HRS) and Asia Pacific Heart Rhythm Society (APHRS). Europace. 2017; 19(2): 190–225.
  12. Hughes JR, Amori G, Hatsukami DK. A survey of physician advice about caffeine. J Subst Abuse. 1988; 1(1): 67–70.
  13. Groh CA, Faulkner M, Getabecha S, et al. Patient-reported triggers of paroxysmal atrial fibrillation. Heart Rhythm. 2019; 16(7): 996–1002.
  14. Rao NZ, Fuller M, Grim MD. Physiochemical characteristics of hot and cold brew coffee chemistry: the effects of roast level and brewing temperature on compound extraction. Foods. 2020; 9(7).
  15. Keng-Chee SA, Wan-Sinn Y, Keng-Chong W, et al. Comparative study of the volatile constituents of southeast asian Coffea arabica, Coffea liberica and Coffea robusta green beans and their antioxidant activities. J Essent Oil Bearing Plants. 2015; 18: 64–73.
  16. Rubayiza AB, Meurens M. Chemical discrimination of arabica and robusta coffees by Fourier transform Raman spectroscopy. J Agric Food Chem. 2005; 53(12): 4654–4659.
  17. Romualdo GR, Rocha AB, Vinken M, et al. Drinking for protection? Epidemiological and experimental evidence on the beneficial effects of coffee or major coffee compounds against gastrointestinal and liver carcinogenesis. Food Res Int. 2019; 123: 567–589.
  18. Gonzalez de Mejia E, Ramirez-Mares MV. Impact of caffeine and coffee on our health. Trends Endocrinol Metab. 2014; 25(10): 489–492.
  19. de Melo Pereira GV, de Carvalho Neto DP, Magalhães Júnior AI, et al. Chemical composition and health properties of coffee and coffee by-products. Adv Food Nutr Res. 2020; 91: 65–96.
  20. Wintgens J. Coffee: growing, processing, sustainable production. A guidebook for growers, processors, traders and researchers. Wiley-VCH, Weinheim 2009: 797–817.
  21. Nieber K. The impact of coffee on health. Planta Med. 2017; 83(16): 1256–1263.
  22. Eun JB, Jo MY, Im JS. Physicochemical characteristics of coffee extracts using different extraction methods. Korean J Food Sci Technol. 2014; 46(6): 723–728.
  23. McCusker RR, Goldberger BA, Cone EJ. Caffeine content of specialty coffees. J Anal Toxicol. 2003; 27(7): 520–522.
  24. Voskoboinik A, Kalman JM, Kistler PM. Caffeine and arrhythmias: time to grind the data. JACC Clin Electrophysiol. 2018; 4(4): 425–432.
  25. Voskoboinik A, Koh Y, Kistler PM. Cardiovascular effects of caffeinated beverages. Trends Cardiovasc Med. 2019; 29(6): 345–350.
  26. Voskoboinik A, Prabhu S, Sugumar H, et al. Effect of dietary factors on cardiac rhythm. Am J Cardiol. 2018; 122(7): 1265–1271.
  27. Tulsian NK, Krishnamurthy S, Anand GS. Channeling of cAMP in PDE-PKA complexes promotes signal adaptation. Biophys J. 2017; 112(12): 2552–2566.
  28. Spadari RC, Cavadas C, de Carvalho AE, et al. Role of beta-adrenergic receptors and sirtuin signaling in the heart during aging, heart failure, and adaptation to stress. Cell Mol Neurobiol. 2018; 38(1): 109–120.
  29. Woll KA, Van Petegem F. Calcium-release channels: structure and function of IP receptors and ryanodine receptors. Physiol Rev. 2022; 102(1): 209–268.
  30. Artin B, Singh M, Richeh C, et al. Caffeine-related atrial fibrillation. Am J Ther. 2010; 17(5): e169–e171.
  31. Huke S, Knollmann BC. Increased myofilament Ca2+-sensitivity and arrhythmia susceptibility. J Mol Cell Cardiol. 2010; 48(5): 824–833.
  32. Pohanka M, Dobes P. Caffeine inhibits acetylcholinesterase, but not butyrylcholinesterase. Int J Mol Sci. 2013; 14(5): 9873–9882.
  33. Guieu R, Deharo JC, Maille B, et al. Adenosine and the cardiovascular system: the good and the bad. J Clin Med. 2020; 9(5).
  34. Metro D, Cernaro V, Santoro D, et al. Beneficial effects of oral pure caffeine on oxidative stress. J Clin Transl Endocrinol. 2017; 10: 22–27.
  35. Richelle M, Tavazzi I, Offord E. Comparison of the antioxidant activity of commonly consumed polyphenolic beverages (coffee, cocoa, and tea) prepared per cup serving. J Agric Food Chem. 2001; 49(7): 3438–3442.
  36. Olechno E, Puścion-Jakubik A, Socha K, et al. Coffee infusions: can they be a source of microelements with antioxidant properties? Antioxidants (Basel). 2021; 10(11).
  37. Jung S, Kim MH, Park JH, et al. Cellular antioxidant and anti-inflammatory effects of coffee extracts with different roasting levels. J Med Food. 2017; 20(6): 626–635.
  38. Paiva C, Beserra B, Reis C, et al. Consumption of coffee or caffeine and serum concentration of inflammatory markers: A systematic review. Crit Rev Food Sci Nutr. 2019; 59(4): 652–663.
  39. Tian L, Su CP, Wang Q, et al. Chlorogenic acid: a potent molecule that protects cardiomyocytes from TNF-α-induced injury via inhibiting NF-κB and JNK signals. J Cell Mol Med. 2019; 23(7): 4666–4678.
  40. Qin L, Zang M, Xu Y, et al. Chlorogenic acid alleviates hyperglycemia-induced cardiac fibrosis through activation of the NO/cGMP/PKG pathway in cardiac fibroblasts. Mol Nutr Food Res. 2021; 65(2): e2000810.
  41. Liu JC, Chen PY, Hao WR, et al. Cafestol inhibits high-glucose-induced cardiac fibrosis in cardiac fibroblasts and type 1-like diabetic rats. Evid Based Complement Alternat Med. 2020; 2020: 4503747.
  42. Uto-Kondo H, Ayaori M, Ogura M, et al. Coffee consumption enhances high-density lipoprotein-mediated cholesterol efflux in macrophages. Circ Res. 2010; 106(4): 779–787.
  43. Gebeyehu GM, Feleke DG, Molla MD, et al. Effect of habitual consumption of Ethiopian Arabica coffee on the risk of cardiovascular diseases among non-diabetic healthy adults. Heliyon. 2020; 6(9): e04886.
  44. Hsu TW, Tantoh DM, Lee KJ, et al. Genetic and non-genetic factor-adjusted association between coffee drinking and high-density lipoprotein cholesterol in Taiwanese adults: stratification by sex. Nutrients. 2019; 11(5).
  45. Beller E, Lorbeer R, Keeser D, et al. Significant impact of coffee consumption on MR-based measures of cardiac function in a population-based cohort study without manifest cardiovascular disease. Nutrients. 2021; 13(4).
  46. Stevens LM, Linstead E, Hall JL, et al. Association between coffee intake and incident heart failure risk: a machine learning analysis of the FHS, the ARIC study, and the CHS. Circ Heart Fail. 2021; 14(2): e006799.
  47. Svingen GFT, Zuo H, Ueland PM, et al. Increased plasma trimethylamine-N-oxide is associated with incident atrial fibrillation. Int J Cardiol. 2018; 267: 100–106.
  48. Gawałko M, Agbaedeng TA, Saljic A, et al. Gut microbiota, dysbiosis and atrial fibrillation. Arrhythmogenic mechanisms and potential clinical implications. Cardiovasc Res. 2021 [Epub ahead of print].
  49. Zhou W, Cheng Y, Zhu P, et al. The gut microbiota and its implication in the development of atherosclerosis and related cardiovascular diseases. Nutrients. 2020; 12(3): 5394096.
  50. Iglesias-Carres L, Essenmacher LA, Racine KC, et al. Development of a high-throughput method to study the inhibitory effect of phytochemicals on trimethylamine formation. Nutrients. 2021; 13(5).
  51. González S, Salazar N, Ruiz-Saavedra S, et al. Long-term coffee consumption is associated with fecal microbial composition in humans. Nutrients. 2020; 12(5).
  52. Mills CE, Tzounis X, Oruna-Concha MJ, et al. In vitro colonic metabolism of coffee and chlorogenic acid results in selective changes in human faecal microbiota growth. Br J Nutr. 2015; 113(8): 1220–1227.
  53. Bartolomaeus H, Balogh A, Yakoub M, et al. Short-chain fatty acid propionate protects from hypertensive cardiovascular damage. Circulation. 2019; 139(11): 1407–1421.
  54. Park KY, Kim HJ, Ahn HS, et al. Effects of coffee consumption on serum uric acid: systematic review and meta-analysis. Semin Arthritis Rheum. 2016; 45(5): 580–586.
  55. Deng Y, Liu F, Yang X, et al. The key role of uric acid in oxidative stress, inflammation, fibrosis, apoptosis, and immunity in the pathogenesis of atrial fibrillation. Front Cardiovasc Med. 2021; 8: 641136.
  56. Sivalokanathan S, Małek ŁA, Malhotra A. The cardiac effects of performance-enhancing medications: caffeine vs. anabolic androgenic steroids. Diagnostics (Basel). 2021; 11(2).
  57. Torquati L, Peeters G, Brown WJ, et al. A daily cup of tea or coffee may keep you moving: association between tea and coffee consumption and physical activity. Int J Environ Res Public Health. 2018; 15(9).
  58. Elliott AD, Linz D, Mishima R, et al. Association between physical activity and risk of incident arrhythmias in 402 406 individuals: evidence from the UK Biobank cohort. Eur Heart J. 2020; 41(15): 1479–1486.
  59. Marcus GM, Modrow MF, Schmid CH, et al. Individualized studies of triggers of paroxysmal atrial fibrillation: the I-STOP-AFib randomized clinical trial. JAMA Cardiol. 2022; 7(2): 167–174.
  60. Marcus GM, Rosenthal DG, Nah G, et al. The coffee and real-time atrial and ventricular ectopy (CRAVE) trial. AHA Congress 2021 — oral presentation.
  61. Krittanawong C, Tunhasiriwet A, Wang Z, et al. Is caffeine or coffee consumption a risk for new-onset atrial fibrillation? A systematic review and meta-analysis. Eur J Prev Cardiol. 2020 [Epub ahead of print]; 28(12): 2047487320908385–e15.
  62. Bazal P, Gea A, Navarro AM, et al. Caffeinated coffee consumption and risk of atrial fibrillation in two Spanish cohorts. Eur J Prev Cardiol. 2021; 28(6): 648–657.
  63. Kim EJ, Hoffmann TJ, Nah G, et al. Coffee consumption and incident tachyarrhythmias: reported behavior, Mendelian randomization, and their interactions. JAMA Intern Med. 2021; 181(9): 1185–1193.
  64. Signori C, Meessen JM, Laaksonen R, et al. Coffee, atrial fibrillation, and circulating ceramides in patients with chronic heart failure. J Agric Food Chem. 2021; 69(38): 11236–11245.
  65. Yuan S, Carter P, Mason AM, et al. Coffee consumption and cardiovascular diseases: a Mendelian randomization study. Nutrients. 2021; 13(7).
  66. Yuan S, Larsson SC. No association between coffee consumption and risk of atrial fibrillation: a Mendelian randomization study. Nutr Metab Cardiovasc Dis. 2019; 29(11): 1185–1188.
  67. Bodar V, Chen J, Gaziano JM, et al. Coffee consumption and risk of atrial fibrillation in the Physicians' Health Study. J Am Heart Assoc. 2019; 8(15): e011346.
  68. Xu J, Fan W, Budoff MJ, et al. Intermittent nonhabitual coffee consumption and risk of atrial fibrillation: the multi-ethnic study of atherosclerosis. J Atr Fibrillation. 2019; 12(1): 2205.
  69. Abdelfattah R, Kamran H, Lazar J, et al. Does caffeine consumption increase the risk of new-onset atrial fibrillation? Cardiology. 2018; 140(2): 106–114.
  70. Casiglia E, Tikhonoff V, Albertini F, et al. Caffeine intake reduces incident atrial fibrillation at a population level. Eur J Prev Cardiol. 2018; 25(10): 1055–1062.
  71. Mostofsky E, Johansen MB, Lundbye-Christensen S, et al. Risk of atrial fibrillation associated with coffee intake: findings from the Danish diet, Cancer, and Health study. Eur J Prev Cardiol. 2016; 23(9): 922–930.
  72. Dixit S, Stein PK, Dewland TA, et al. Consumption of caffeinated products and cardiac ectopy. J Am Heart Assoc. 2016; 5(1).
  73. Larsson SC, Drca N, Jensen-Urstad M, et al. Coffee consumption is not associated with increased risk of atrial fibrillation: results from two prospective cohorts and a meta-analysis. BMC Med. 2015; 13: 207.
  74. Cheng M, Hu Z, Lu X, et al. Caffeine intake and atrial fibrillation incidence: dose response meta-analysis of prospective cohort studies. Can J Cardiol. 2014; 30(4): 448–454.
  75. Caldeira D, Martins C, Alves LB, et al. Caffeine does not increase the risk of atrial fibrillation: a systematic review and meta-analysis of observational studies. Heart. 2013; 99(19): 1383–1389.
  76. Klatsky AL, Hasan AS, Armstrong MA, et al. Coffee, caffeine, and risk of hospitalization for arrhythmias. Perm J. 2011; 15(3): 19–25.
  77. Mattioli AV, Farinetti A, Miloro C, et al. Influence of coffee and caffeine consumption on atrial fibrillation in hypertensive patients. Nutr Metab Cardiovasc Dis. 2011; 21(6): 412–417.
  78. Shen J, Johnson VM, Sullivan LM, et al. Dietary factors and incident atrial fibrillation: the Framingham Heart Study. Am J Clin Nutr. 2011; 93(2): 261–266.
  79. Conen D, Chiuve SE, Everett BM, et al. Caffeine consumption and incident atrial fibrillation in women. Am J Clin Nutr. 2010; 92(3): 509–514.
  80. Mukamal KJ, Hallqvist J, Hammar N, et al. Coffee consumption and mortality after acute myocardial infarction: the Stockholm Heart Epidemiology Program. Am Heart J. 2009; 157(3): 495–501.
  81. Mattioli AV, Bonatti S, Zennaro M, et al. Effect of coffee consumption, lifestyle and acute life stress in the development of acute lone atrial fibrillation. J Cardiovasc Med (Hagerstown). 2008; 9(8): 794–798.
  82. Frost L, Vestergaard P. Caffeine and risk of atrial fibrillation or flutter: the Danish Diet, Cancer, and Health Study. Am J Clin Nutr. 2005; 81(3): 578–582.
  83. Mattioli AV, Bonatti S, Zennaro M, et al. The relationship between personality, socio-economic factors, acute life stress and the development, spontaneous conversion and recurrences of acute lone atrial fibrillation. Europace. 2005; 7(3): 211–220.
  84. Wilhelmsen L, Rosengren A, Lappas G. Hospitalizations for atrial fibrillation in the general male population: morbidity and risk factors. J Intern Med. 2001; 250(5): 382–389.
  85. Zuchinali P, Souza GC, Pimentel M, et al. Short-term effects of high-dose caffeine on cardiac arrhythmias in patients with heart failure: a randomized clinical trial. JAMA Intern Med. 2016; 176(12): 1752–1759.
  86. Zuchinali P, Ribeiro PAB, Pimentel M, et al. Effect of caffeine on ventricular arrhythmia: a systematic review and meta-analysis of experimental and clinical studies. Europace. 2016; 18(2): 257–266.
  87. Bertoia ML, Triche EW, Michaud DS, et al. Long-term alcohol and caffeine intake and risk of sudden cardiac death in women. Am J Clin Nutr. 2013; 97(6): 1356–1363.
  88. de Vreede-Swagemakers JJ, Gorgels AP, Weijenberg MP, et al. Risk indicators for out-of-hospital cardiac arrest in patients with coronary artery disease. J Clin Epidemiol. 1999; 52(7): 601–607.
  89. Newby DE, Neilson JM, Jarvie DR, et al. Caffeine restriction has no role in the management of patients with symptomatic idiopathic ventricular premature beats. Heart. 1996; 76(4): 355–357.
  90. Myers MG, Harris L. High dose caffeine and ventricular arrhythmias. Can J Cardiol. 1990; 6(3): 95–98.
  91. Graboys TB, Blatt CM, Lown B. The effect of caffeine on ventricular ectopic activity in patients with malignant ventricular arrhythmia. Arch Intern Med. 1989; 149(3): 637–639.
  92. Myers MG, Harris L, Leenen FH, et al. Caffeine as a possible cause of ventricular arrhythmias during the healing phase of acute myocardial infarction. Am J Cardiol. 1987; 59(12): 1024–1028.
  93. Prineas RJ, Jacobs DR, Crow RS, et al. Coffee, tea and VPB. J Chronic Dis. 1980; 33(2): 67–72.
  94. de Oliveira RA, Araújo LF, de Figueiredo RC, et al. Coffee consumption and heart rate variability: the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) Cohort Study. Nutrients. 2017; 9(7).
  95. Lemery R, Pecarskie A, Bernick J, et al. A prospective placebo controlled randomized study of caffeine in patients with supraventricular tachycardia undergoing electrophysiologic testing. J Cardiovasc Electrophysiol. 2015; 26(1): 1–6.
  96. Notarius CF, Floras JS. Caffeine enhances heart rate variability in middle-aged healthy, but not heart failure subjects. J Caffeine Res. 2012; 2(2): 77–82.
  97. Richardson T, Baker J, Thomas PW, et al. Randomized control trial investigating the influence of coffee on heart rate variability in patients with ST-segment elevation myocardial infarction. QJM. 2009; 102(8): 555–561.
  98. Strubelt O, Diederich KW. Experimental treatment of the acute cardiovascular toxicity of caffeine. J Toxicol Clin Toxicol. 1999; 37(1): 29–33.
  99. Robertson D, Frölich JC, Carr RK, et al. Effects of caffeine on plasma renin activity, catecholamines and blood pressure. N Engl J Med. 1978; 298(4): 181–186.
  100. Fabrizio C, Desiderio M, Coyne RF. Electrocardiogram abnormalities of caffeine overdose. Circ Arrhythm Electrophysiol. 2016; 9(7).
  101. Nwabuo CC, Betoko AS, Reis JP, et al. Coffee and tea consumption in the early adult lifespan and left ventricular function in middle age: the CARDIA study. ESC Heart Fail. 2020; 7(4): 1510–1519.
  102. Karabegović I, Portilla-Fernandez E, Li Y, et al. Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption. Nat Commun. 2021; 12(1): 2830.
  103. Ek WE, Tobi EW, Ahsan M, et al. Epigenome-Wide Association Study Consortium. Tea and coffee consumption in relation to DNA methylation in four European cohorts. Hum Mol Genet. 2017; 26(16): 3221–3231.
  104. Hyppönen E, Zhou A. Cardiovascular symptoms affect the patterns of habitual coffee consumption. Am J Clin Nutr. 2021; 114(1): 214–219.