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Vol 16, No 1 (2021)
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Published online: 2021-02-27

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The CHA2DS2-VASc score as a predictor of dementia in elderly patients with atrial fibrillation

Katarzyna Lomper1, Beata Jankowska-Polańska1, Joanna Jaroch2, Maria Łoboz-Rudnicka2, Krzysztof Dudek3, Krystyna Łoboz-Grudzień2
Folia Cardiologica 2021;16(1):1-7.

Abstract

Introduction. Many studies suggest that atrial fibrillation (AF) is associated with an increased risk of functional decline and may contribute to the development of dementia. It is not known whether the CHA2DS2-VASc scale allows the development of dementia in patients with AF to be predicted. To assess whether CHA2DS2-VASc score can be a predictor of dementia evaluated with Mini-Mental State Examination (MMSE) questionnaire in the elderly patients with atrial fibrillation. Material and methods. The study included 157 patients (mean age 73.4) with non-valvular atrial fibrillation and no history of stroke. The presence of dementia was defined as the MMSE score of ≤ 23 points. Results. The univariate analysis revealed that age (b = 0.132, p < 0.001), heart failure (b = 0.786, p = 0.033) and CHA2DS2-VASc score were significant determinants of dementia. In multivariate analysis, the CHA2DS2-VASc score was proved to be an independent determinant of dementia (β = 0.385, p = 0.003). Prevalence of dementia was one and a half times higher in the group of patients with a CHA2DS2-VASc score > 4 points (odds ratio = 0.47) that in the group of patients with CHA2DS2-VASc score ≤ 4 points. Conclusion. The CHA2DS2-VASc score is a useful predictor of dementia in the ageing population with atrial fibrillation without clinical stroke.

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