open access

Vol 14, No 5 (2019)
Heart failure
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Sacubitril/valsartan predischarge for patient in acute heart failure with reduced ejection fraction of left ventricle — the earlier, the better

Małgorzata Lelonek
Folia Cardiologica 2019;14(5):516-521.

open access

Vol 14, No 5 (2019)
Heart failure

Abstract

Based on results of trials TRANSITION and PIONIEER-HF the Heart Failure Association of the European Society of Cardiology reported an expert consensus 2019 that the initiation of sacubitril/valsartan rather than an angiotensin-converting enzyme (ACE) inhibitors or an angiotensin II type 1 receptor blocker may be considered for patients hospitalized with new-onset heart failure with reduced ejection fraction (HFrEF) or decompensated chronic HFrEF to reduce the short-term risk of adverse events and to simplify management by avoiding the need to titrate ACE inhibitors first and then switch to angiotensin receptor neprilysin inhibitor (ARNI). The paper described the new data from the two trials TRANSITION and PIONIEER-HF.

Abstract

Based on results of trials TRANSITION and PIONIEER-HF the Heart Failure Association of the European Society of Cardiology reported an expert consensus 2019 that the initiation of sacubitril/valsartan rather than an angiotensin-converting enzyme (ACE) inhibitors or an angiotensin II type 1 receptor blocker may be considered for patients hospitalized with new-onset heart failure with reduced ejection fraction (HFrEF) or decompensated chronic HFrEF to reduce the short-term risk of adverse events and to simplify management by avoiding the need to titrate ACE inhibitors first and then switch to angiotensin receptor neprilysin inhibitor (ARNI). The paper described the new data from the two trials TRANSITION and PIONIEER-HF.

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Keywords

sacubitril/valsartan, acute heart failure, HFrEF, predischarge

About this article
Title

Sacubitril/valsartan predischarge for patient in acute heart failure with reduced ejection fraction of left ventricle — the earlier, the better

Journal

Folia Cardiologica

Issue

Vol 14, No 5 (2019)

Pages

516-521

Bibliographic record

Folia Cardiologica 2019;14(5):516-521.

Keywords

sacubitril/valsartan
acute heart failure
HFrEF
predischarge

Authors

Małgorzata Lelonek

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