open access

Vol 14, No 3 (2019)
Review Papers
Published online: 2019-07-04
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Acute liver failure after administration of amiodarone

Olga Wajtryt, Tadeusz M. Zielonka
Folia Cardiologica 2019;14(3):247-251.

open access

Vol 14, No 3 (2019)
Review Papers
Published online: 2019-07-04

Abstract

Amiodarone is an anti-arrhythmic medicine used in the treatment of heart arrhythmias. Due to its long half-life, lipophilic structure, and accumulation in the tissues of the thyroid, liver, lung, cornea and skin, it can cause many adverse effects. Acute liver failure is a rare complication following the administration of amiodarone. Several dozen cases of acute liver failure after administration of amiodarone have been described. Its mechanism is not yet clearly known. It has been suggested that emulsifier of the intravenous form of the drug (polysorbate 80) could be a reason for the disorder, but it also occurs after oral administration. The diagnosis can be established when amiodarone results in liver failure with encephalopathy and blood coagulation disorders, excluding other hepatotoxic factors. The recommendations for the management of this disease have not yet been established. However, the prognosis is serious because high mortality has been observed.

Abstract

Amiodarone is an anti-arrhythmic medicine used in the treatment of heart arrhythmias. Due to its long half-life, lipophilic structure, and accumulation in the tissues of the thyroid, liver, lung, cornea and skin, it can cause many adverse effects. Acute liver failure is a rare complication following the administration of amiodarone. Several dozen cases of acute liver failure after administration of amiodarone have been described. Its mechanism is not yet clearly known. It has been suggested that emulsifier of the intravenous form of the drug (polysorbate 80) could be a reason for the disorder, but it also occurs after oral administration. The diagnosis can be established when amiodarone results in liver failure with encephalopathy and blood coagulation disorders, excluding other hepatotoxic factors. The recommendations for the management of this disease have not yet been established. However, the prognosis is serious because high mortality has been observed.
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Keywords

amiodarone; adverse effect; acute liver failure; drug-induced liver injury; polysorbate 80

About this article
Title

Acute liver failure after administration of amiodarone

Journal

Folia Cardiologica

Issue

Vol 14, No 3 (2019)

Pages

247-251

Published online

2019-07-04

Bibliographic record

Folia Cardiologica 2019;14(3):247-251.

Keywords

amiodarone
adverse effect
acute liver failure
drug-induced liver injury
polysorbate 80

Authors

Olga Wajtryt
Tadeusz M. Zielonka

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