open access

Vol 14, No 1 (2019)
Original Papers
Published online: 2019-04-10
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Risk of mortality in infective endocarditis — a single-centre experience

Klaudia Wołynkiewicz, Agnieszka Kołodzińska, Diana Paskudzka, Krzysztof Krasuski, Marcin Grabowski, Krzysztof J Filipiak, Grzegorz Opolski
DOI: 10.5603/FC.2019.0007
·
Folia Cardiologica 2019;14(1):19-23.

open access

Vol 14, No 1 (2019)
Original Papers
Published online: 2019-04-10

Abstract

Introduction. Infective endocarditis (IE) is a disease associated with high morbidity and mortality. Multiple risk factors have been identified for mortality in IE.  Material and methods. 21 patients diagnosed with IE between January 2018 and January 2019 were retrospectively analysed. All data was expressed as mean ± standard error (SE). Variables were analysed with chi-square, Fisher’s exact, and Mann-Whitney tests. A p-value < 0.05 was identified as statistically significant.  Results. Total mortality was 52.4% and in-hospital mortality was 28.6%. Patients who died in the course of IE were older compared to survivors (66.7 ± 19.8 years vs 70.8 ± 11.6). Staphylococci and Streptococci spp. were causative patho- gens in 71.4% of cases of IE. Morphology was the most important feature that identified patients who died: white blood cells were higher in non-survivors (35.39 ± 14.36 vs 12.02 ± 4.67, p < 0.05); haemoglobin level was decreased (7.47 ± 0.96 vs 9.51 ± 1.33, p < 0.05); and thrombocytopenia (82.50 ± 45.85 vs 179.8 ± 56.13, p < 0.05) was characteristic for non-survivors. The plates-to-leucocytes ratio in patients who died during hospitalisation was 3.01 ± 2.89. For patients who survived hospitalisation it was 15.10 ± 10.86 (p = 0.0069). Similar results were achieved when comparing patients who died during hospitalisation 3.01 ± 2.89 vs patients who survived until 2019 16.94 ± 12.62 (p = 0.004662).  Conclusion. Morphology is recommended as the key diagnostic test in predicting mortality risk in patients with IE. The plates-to-leucocytes ratio is also a significant marker of mortality. Prompt identification and close monitoring of risk factors may prevent a higher mortality rate in IE. 

Abstract

Introduction. Infective endocarditis (IE) is a disease associated with high morbidity and mortality. Multiple risk factors have been identified for mortality in IE.  Material and methods. 21 patients diagnosed with IE between January 2018 and January 2019 were retrospectively analysed. All data was expressed as mean ± standard error (SE). Variables were analysed with chi-square, Fisher’s exact, and Mann-Whitney tests. A p-value < 0.05 was identified as statistically significant.  Results. Total mortality was 52.4% and in-hospital mortality was 28.6%. Patients who died in the course of IE were older compared to survivors (66.7 ± 19.8 years vs 70.8 ± 11.6). Staphylococci and Streptococci spp. were causative patho- gens in 71.4% of cases of IE. Morphology was the most important feature that identified patients who died: white blood cells were higher in non-survivors (35.39 ± 14.36 vs 12.02 ± 4.67, p < 0.05); haemoglobin level was decreased (7.47 ± 0.96 vs 9.51 ± 1.33, p < 0.05); and thrombocytopenia (82.50 ± 45.85 vs 179.8 ± 56.13, p < 0.05) was characteristic for non-survivors. The plates-to-leucocytes ratio in patients who died during hospitalisation was 3.01 ± 2.89. For patients who survived hospitalisation it was 15.10 ± 10.86 (p = 0.0069). Similar results were achieved when comparing patients who died during hospitalisation 3.01 ± 2.89 vs patients who survived until 2019 16.94 ± 12.62 (p = 0.004662).  Conclusion. Morphology is recommended as the key diagnostic test in predicting mortality risk in patients with IE. The plates-to-leucocytes ratio is also a significant marker of mortality. Prompt identification and close monitoring of risk factors may prevent a higher mortality rate in IE. 
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Keywords

infective endocarditis; risk factors of infective endocarditis; mortality in infective endocarditis

About this article
Title

Risk of mortality in infective endocarditis — a single-centre experience

Journal

Folia Cardiologica

Issue

Vol 14, No 1 (2019)

Pages

19-23

Published online

2019-04-10

DOI

10.5603/FC.2019.0007

Bibliographic record

Folia Cardiologica 2019;14(1):19-23.

Keywords

infective endocarditis
risk factors of infective endocarditis
mortality in infective endocarditis

Authors

Klaudia Wołynkiewicz
Agnieszka Kołodzińska
Diana Paskudzka
Krzysztof Krasuski
Marcin Grabowski
Krzysztof J Filipiak
Grzegorz Opolski

References (12)
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