open access

Vol 12, No 6 (2017)
Original Papers
Published online: 2017-12-29
Get Citation

A study of coronary artery disease in young patients

Sabiye Yılmaz, Hüseyin Gündüz, Perihan Varım, Mehmet Bülent Vatan, Saadet Demirtaş, Mehmet Akif Çakar, Ercan Aydın, Ersan Tatlı, Mustafa Tarık Ağaç
DOI: 10.5603/FC.2017.0104
·
Folia Cardiologica 2017;12(6):543-550.

open access

Vol 12, No 6 (2017)
Original Papers
Published online: 2017-12-29

Abstract

Introduction. An increasing number of younger patients are being hospitalized with acute coronary syndromes. Earlier risk assessment is essential to prevent or delay coronary artery disease (CAD). This study aimed to assess the rate, risk factor profile, presentation, management and prognosis in young patients with CAD and compared with the same age group without CAD. Material and methods. In this retrospective study, 4325 patients who had undergone coronary angiography from 2011 to 2014 were identified. A total of 627 patients were ≤ 45 years age; 412 of them had CAD, and 215 had normal coronary arteries (control group). Results. The mean age of the patients was 41.7 ± 4.1 years in the CAD group and 41.5 ± 4.5 years in the control group. The prevalences of dyslipidemia, smoking, family history of CAD, hypertension, diabetes, and overweight were higher in the CAD than in the control group. However, the obesity rate was not significantly different between the two groups. Patients with ACS often presented with ST elevation myocardial infarction (STEMI) (49.3%), and single-vessel involvement (55.3%) predominated. Percutaneous coronary intervention (PCI) was the main myocardial reperfusion therapy (68.4%). Conclusıons. Among the young patients studied, CAD had a higher incidence in males. Smoking was the most important modifiable risk factor. Also, patients showed high prevalences of dyslipidemia, overweight, diabetes, and family history of CAD. This study re-emphasizes the relationship between traditional cardiovascular risks and CAD in young.

Abstract

Introduction. An increasing number of younger patients are being hospitalized with acute coronary syndromes. Earlier risk assessment is essential to prevent or delay coronary artery disease (CAD). This study aimed to assess the rate, risk factor profile, presentation, management and prognosis in young patients with CAD and compared with the same age group without CAD. Material and methods. In this retrospective study, 4325 patients who had undergone coronary angiography from 2011 to 2014 were identified. A total of 627 patients were ≤ 45 years age; 412 of them had CAD, and 215 had normal coronary arteries (control group). Results. The mean age of the patients was 41.7 ± 4.1 years in the CAD group and 41.5 ± 4.5 years in the control group. The prevalences of dyslipidemia, smoking, family history of CAD, hypertension, diabetes, and overweight were higher in the CAD than in the control group. However, the obesity rate was not significantly different between the two groups. Patients with ACS often presented with ST elevation myocardial infarction (STEMI) (49.3%), and single-vessel involvement (55.3%) predominated. Percutaneous coronary intervention (PCI) was the main myocardial reperfusion therapy (68.4%). Conclusıons. Among the young patients studied, CAD had a higher incidence in males. Smoking was the most important modifiable risk factor. Also, patients showed high prevalences of dyslipidemia, overweight, diabetes, and family history of CAD. This study re-emphasizes the relationship between traditional cardiovascular risks and CAD in young.
Get Citation

Keywords

coronary artery disease, young adults, coronary angiography

About this article
Title

A study of coronary artery disease in young patients

Journal

Folia Cardiologica

Issue

Vol 12, No 6 (2017)

Pages

543-550

Published online

2017-12-29

DOI

10.5603/FC.2017.0104

Bibliographic record

Folia Cardiologica 2017;12(6):543-550.

Keywords

coronary artery disease
young adults
coronary angiography

Authors

Sabiye Yılmaz
Hüseyin Gündüz
Perihan Varım
Mehmet Bülent Vatan
Saadet Demirtaş
Mehmet Akif Çakar
Ercan Aydın
Ersan Tatlı
Mustafa Tarık Ağaç

References (25)
  1. Zimmerman FH, Cameron A, Fisher LD, et al. Myocardial infarction in young adults: angiographic characterization, risk factors and prognosis (Coronary Artery Surgery Study Registry). J Am Coll Cardiol. 1995; 26(3): 654–661.
  2. Doughty M, Mehta R, Bruckman D, et al. Acute myocardial infarction in the young--The University of Michigan experience. Am Heart J. 2002; 143(1): 56–62.
  3. Morillas P, Bertomeu V, Pabón P, et al. PRIAMHO II Investigators. Characteristics and outcome of acute myocardial infarction in young patients. The PRIAMHO II study. Cardiology. 2007; 107(4): 217–225.
  4. Akosah KO, Schaper A, Cogbill C, et al. Preventing myocardial infarction in the young adult in the first place: how do the National Cholesterol Education Panel III guidelines perform? J Am Coll Cardiol. 2003; 41(9): 1475–1479.
  5. Barbash GI, White HD, Modan M, et al. Acute myocardial infarction in the young--the role of smoking. The Investigators of the International Tissue Plasminogen Activator/Streptokinase Mortality Trial. Eur Heart J. 1995; 16(3): 313–316.
  6. Shiraishi J, Kohno Y, Yamaguchi S, et al. AMI-Kyoto Multi-Center Risk Study Group. Acute myocardial infarction in young Japanese adults. Circ J. 2005; 69(12): 1454–1458.
  7. Schoenenberger AW, Radovanovic D, Stauffer JC, et al. AMIS Plus Investigators. Acute coronary syndromes in young patients: presentation, treatment and outcome. Int J Cardiol. 2011; 148(3): 300–304.
  8. Matsis K, Holley A, Al-Sinan A, et al. Differing Clinical Characteristics Between Young and Older Patients Presenting with Myocardial Infarction. Heart Lung Circ. 2017; 26(6): 566–571.
  9. Shah N, Kelly AM, Cox N, et al. Myocardial infarction in the "young": risk factors, presentation, management and prognosis. Heart Lung Circ. 2016; 25(10): 955–960.
  10. Fournier JA, Sánchez-González A, Quero J, et al. Normal angiogram after myocardial infarction in young patients: a prospective clinical-angiographic and long-term follow-up study. Int J Cardiol. 1997; 60(3): 281–287.
  11. Kannel W, McGee D, Castelli W. Latest perspectives on cigarette smoking and cardiovascular disease: the Framingham Study. J Card Rehabil. 1984; 4: 267–77.
  12. Cullen P. Evidence that triglycerides are an independent coronary heart disease risk factor. Am J Cardiol. 2000; 86(9): 943–949.
  13. Li Z, Huang Ji, Li N. Predictive and Prognostic Value of High-density Lipoprotein Cholesterol in Young Male Patients with Acute Myocardial Infarction. Chin Med J (Engl). 2017; 130(1): 77–82.
  14. Mahoney LT, Burns TL, Stanford W, et al. Usefulness of the Framingham risk score and body mass index to predict early coronary artery calcium in young adults (Muscatine Study). Am J Cardiol. 2001; 88(5): 509–515.
  15. Uhl GS, Farrell PW. Myocardial infarction in young adults: risk factors and natural history. Am Heart J. 1983; 105(4): 548–553.
  16. Krolewski AS, Kosinski EJ, Warram JH, et al. Magnitude and determinants of coronary artery disease in juvenile-onset, insulin-dependent diabetes mellitus. Am J Cardiol. 1987; 59(8): 750–755.
  17. Malmberg K, Båvenholm P, Hamsten A. Clinical and biochemical factors associated with prognosis after myocardial infarction at a young age. J Am Coll Cardiol. 1994; 24(3): 592–599.
  18. British Heart Foundation. BHF coronary heart disease statistics 2003. http://www.bhf.org.uk/professionals/statistics (2003).
  19. Chen L, Chester M, Kaski JC. Clinical factors and angiographic features associated with premature coronary artery disease. Chest. 1995; 108(2): 364–369.
  20. Imazio M, Bobbio M, Bergerone S, et al. Clinical and epidemiological characteristics of juvenile myocardial infarction in Italy: the GISSI experience. G Ital Cardiol. 1998; 28(5): 505–512.
  21. Mansourati J, Da Costa A, Munier S, et al. Prevalence of factor V Leiden in patients with myocardial infarction and normal coronary angiography. Thromb Haemost. 2000; 83(6): 822–825.
  22. Isner JM, Estes NA, Thompson PD, et al. Acute cardiac events temporally related to cocaine abuse. N Engl J Med. 1986; 315(23): 1438–1443.
  23. Huang CN, Wu DJ, Chen KS. Acute myocardial infarction caused by transnasal inhalation of amphetamine. Jpn Heart J. 1993; 34(6): 815–818.
  24. Neves D, Bento Â, Fernandes R, et al. Spontaneous coronary artery dissection: Still a lot to learn. Rev Port Cardiol. 2017; 36(1): 59.e1–59.e5.
  25. Harikrishnan S, Jacob SP, Tharakan J, et al. Congenital coronary anomalies of origin and distribution in adults: a coronary arteriographic study. Indian Heart J. 2002; 54(3): 271–275.

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

 

Wydawcą serwisu jest  "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl