open access

Vol 12, No 1 (2017)
Case Reports
Published online: 2017-03-03
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Myocardial infarction with ST-elevation in a young woman with complex thrombophilia

Anna Kowalczys, Andrzej Mital, Katarzyna Storoniak, Marcin Gruchała
DOI: 10.5603/FC.2017.0012
·
Folia Cardiologica 2017;12(1):96-102.

open access

Vol 12, No 1 (2017)
Case Reports
Published online: 2017-03-03

Abstract

A 31-year-old woman was admitted to the clinic due to severe chest pain. Based on the clinical status and additional tests results myocardial infarction with ST elevation was diagnosed. Urgent coronary angiography and occluded left anterior descending artery recanalization with drug eluting stent implantation were successfully performed and resulted in clinical improvement. Anamnesis revealed two prominent risk factors for atherosclerosis: hypertension and hypercholesterolemia. Laboratory blood test results revealed the presence of complex thrombophilia consisted of: hyperhomocysteinemia, MTHFR gene mutation, protein S deficiency and factor VIII excess. Due to the high risk of thromboembolic complications, rivaroxaban was added to the dual antiplatelet therapy. This case report demonstrates the importance of the determination of additional risk factors in secondary prevention of cardiovascular events in young patients.

Abstract

A 31-year-old woman was admitted to the clinic due to severe chest pain. Based on the clinical status and additional tests results myocardial infarction with ST elevation was diagnosed. Urgent coronary angiography and occluded left anterior descending artery recanalization with drug eluting stent implantation were successfully performed and resulted in clinical improvement. Anamnesis revealed two prominent risk factors for atherosclerosis: hypertension and hypercholesterolemia. Laboratory blood test results revealed the presence of complex thrombophilia consisted of: hyperhomocysteinemia, MTHFR gene mutation, protein S deficiency and factor VIII excess. Due to the high risk of thromboembolic complications, rivaroxaban was added to the dual antiplatelet therapy. This case report demonstrates the importance of the determination of additional risk factors in secondary prevention of cardiovascular events in young patients.

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Keywords

myocardial infarction, complex thrombophilia, hyperhomocysteinemia, MTHFR gene mutation, protein S deficiency, anticoagulant therapy

About this article
Title

Myocardial infarction with ST-elevation in a young woman with complex thrombophilia

Journal

Folia Cardiologica

Issue

Vol 12, No 1 (2017)

Pages

96-102

Published online

2017-03-03

DOI

10.5603/FC.2017.0012

Bibliographic record

Folia Cardiologica 2017;12(1):96-102.

Keywords

myocardial infarction
complex thrombophilia
hyperhomocysteinemia
MTHFR gene mutation
protein S deficiency
anticoagulant therapy

Authors

Anna Kowalczys
Andrzej Mital
Katarzyna Storoniak
Marcin Gruchała

References (10)
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