open access

Vol 10, No 1 (2015)
Young Cardiology
Published online: 2015-03-02
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The complex nature of arterial stiffness in patients with arterial hypertension

Paweł Krzesiński, Adam Stańczyk, Katarzyna Piotrowicz, Grzegorz Gielerak
DOI: 10.5603/FC.2015.0003
·
Folia Cardiologica 2015;10(1):1-7.

open access

Vol 10, No 1 (2015)
Young Cardiology
Published online: 2015-03-02

Abstract

Introduction. The arterial stiffness has become the target of therapeutic interventions in patients with cardiovascular diseases and the ability to characterize and quantify arterial properties turned out to be of importance. Aim of this study was to evaluate the association of arterial stiffness and peripheral blood flow with clinical characteristics and hemodynamics in patients with arterial hypertension (AH).

Material and methods. The study included 150 patients (111 men; mean age 43.5 years) with AH that underwent clinical evaluation and hemodynamic assessment by impedance plethysmography (IPG) and cardiography (ICG), with analysis of i.e. pulse wave velocity (PWV), mean arterial pressure (MAP), heart rate (HR), stroke index (SI), total artery compliance (TAC), systemic vascular resistance (SVRI), pre-ejection period (PEP) and left ventricular ejection time (LVET).

Results. In comparative analysis PWV was significantly higher in women than men (6.18 ± 0.77 vs 5.91 ± 0.99 m/s; p = 0.035). PWV was also associated with age (R = 0.41), MAP (R = 0.32), HR (R = 0.32), SI (R = –0.47), arterial elasticity (TAC, R = –0.31), vascular resistance (SVRI, 0.38) and sub-periods of heart contraction (PEP, R = 0.59 and LVET, 0.28). Age, MAP, PEP and LVET revealed to be the independent covariates in the multivariate regression model for PWV estimation (R square 0.61).

Conclusions. Bioimpedance methods are complementary for the assessment of complexity of the arterial stiffness. PWV revealed to be associated with hemodynamic parameters characterizing ventricular-vascular interactions, including BP, SVRI, TAC, and characteristics of left ventricle performance (HR, SI, PEP, LVET). In view of the classifying value of PWV in cardiovascular risk evaluation the current patient’s hemodynamic state should be carefully considered.

Abstract

Introduction. The arterial stiffness has become the target of therapeutic interventions in patients with cardiovascular diseases and the ability to characterize and quantify arterial properties turned out to be of importance. Aim of this study was to evaluate the association of arterial stiffness and peripheral blood flow with clinical characteristics and hemodynamics in patients with arterial hypertension (AH).

Material and methods. The study included 150 patients (111 men; mean age 43.5 years) with AH that underwent clinical evaluation and hemodynamic assessment by impedance plethysmography (IPG) and cardiography (ICG), with analysis of i.e. pulse wave velocity (PWV), mean arterial pressure (MAP), heart rate (HR), stroke index (SI), total artery compliance (TAC), systemic vascular resistance (SVRI), pre-ejection period (PEP) and left ventricular ejection time (LVET).

Results. In comparative analysis PWV was significantly higher in women than men (6.18 ± 0.77 vs 5.91 ± 0.99 m/s; p = 0.035). PWV was also associated with age (R = 0.41), MAP (R = 0.32), HR (R = 0.32), SI (R = –0.47), arterial elasticity (TAC, R = –0.31), vascular resistance (SVRI, 0.38) and sub-periods of heart contraction (PEP, R = 0.59 and LVET, 0.28). Age, MAP, PEP and LVET revealed to be the independent covariates in the multivariate regression model for PWV estimation (R square 0.61).

Conclusions. Bioimpedance methods are complementary for the assessment of complexity of the arterial stiffness. PWV revealed to be associated with hemodynamic parameters characterizing ventricular-vascular interactions, including BP, SVRI, TAC, and characteristics of left ventricle performance (HR, SI, PEP, LVET). In view of the classifying value of PWV in cardiovascular risk evaluation the current patient’s hemodynamic state should be carefully considered.

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Keywords

arterial hypertension, arterial stiffness, impedance plethysmography, impedance cardiography, pulse wave velocity

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About this article
Title

The complex nature of arterial stiffness in patients with arterial hypertension

Journal

Folia Cardiologica

Issue

Vol 10, No 1 (2015)

Pages

1-7

Published online

2015-03-02

DOI

10.5603/FC.2015.0003

Bibliographic record

Folia Cardiologica 2015;10(1):1-7.

Keywords

arterial hypertension
arterial stiffness
impedance plethysmography
impedance cardiography
pulse wave velocity

Authors

Paweł Krzesiński
Adam Stańczyk
Katarzyna Piotrowicz
Grzegorz Gielerak

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