open access

Vol 9, No 4 (2014)
Review Papers
Published online: 2014-12-22
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Influence of heart failure on P2Y12 receptor blockade in patients with acute coronary syndrome treated with clopidogrel

Małgorzata Molska, Magdalena Kieszkowska, Stanisław Szczerbiński, Zofia Grąbczewska, Aldona Kubica
Folia Cardiologica 2014;9(4):358-363.

open access

Vol 9, No 4 (2014)
Review Papers
Published online: 2014-12-22

Abstract

Clopidogrel belongs to medicines used in the treatment of patients with acute coronary syndrome. This medicine prevents platelet aggregation by blocking P2Y12 receptor. Factors that reduce the availability of active clopidogrel metabolite increase the risk of thrombo-embolic complications, especially in patient who undergo coronary angioplasty. This paper presents the impact of heart failure on effectiveness of clopidogrel therapy.

Abstract

Clopidogrel belongs to medicines used in the treatment of patients with acute coronary syndrome. This medicine prevents platelet aggregation by blocking P2Y12 receptor. Factors that reduce the availability of active clopidogrel metabolite increase the risk of thrombo-embolic complications, especially in patient who undergo coronary angioplasty. This paper presents the impact of heart failure on effectiveness of clopidogrel therapy.

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Keywords

clopidogrel, P2Y12 inhibitors, platelets, heart failure

About this article
Title

Influence of heart failure on P2Y12 receptor blockade in patients with acute coronary syndrome treated with clopidogrel

Journal

Folia Cardiologica

Issue

Vol 9, No 4 (2014)

Pages

358-363

Published online

2014-12-22

Bibliographic record

Folia Cardiologica 2014;9(4):358-363.

Keywords

clopidogrel
P2Y12 inhibitors
platelets
heart failure

Authors

Małgorzata Molska
Magdalena Kieszkowska
Stanisław Szczerbiński
Zofia Grąbczewska
Aldona Kubica

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