open access

Vol 9, No 2 (2014)
Review Papers
Published online: 2014-06-27
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Perindopril — unknown face of a well-known drug

Maciej Krzysztof Kluk, Beata Wożakowska-Kapłon
Folia Cardiologica 2014;9(2):173-178.

open access

Vol 9, No 2 (2014)
Review Papers
Published online: 2014-06-27

Abstract

Perindopril is a very effective ACE inhibitor having numerous beneficial features based on pleiotropic effects which are clinically relevant and enhance cardioprotective and nephroprotective effects of this modern drug. The main pleiotropiceffects of perindopril are: improvement of endothelium function, reduction of oxidative stress, antiinflammatory effect, pro- and antifibrinolytic effects, inhibition of vessel and left ventricle wall remodelling, reduction of central hypertension, increasing sensitivity to insulin. Perindopril was proved to be very effective in various clinical trials, especially in patients with high risk of cardiovascular events, which is also reflected in European Society of Cardiology recommendations. Perindopril is not free from adverse effects, but they seem to be milder when compared to other ACE inhibitors; therefore perindopril may be considered a safe drug.

Abstract

Perindopril is a very effective ACE inhibitor having numerous beneficial features based on pleiotropic effects which are clinically relevant and enhance cardioprotective and nephroprotective effects of this modern drug. The main pleiotropiceffects of perindopril are: improvement of endothelium function, reduction of oxidative stress, antiinflammatory effect, pro- and antifibrinolytic effects, inhibition of vessel and left ventricle wall remodelling, reduction of central hypertension, increasing sensitivity to insulin. Perindopril was proved to be very effective in various clinical trials, especially in patients with high risk of cardiovascular events, which is also reflected in European Society of Cardiology recommendations. Perindopril is not free from adverse effects, but they seem to be milder when compared to other ACE inhibitors; therefore perindopril may be considered a safe drug.
Get Citation

Keywords

perindopril, pleiotropic effects

About this article
Title

Perindopril — unknown face of a well-known drug

Journal

Folia Cardiologica

Issue

Vol 9, No 2 (2014)

Pages

173-178

Published online

2014-06-27

Bibliographic record

Folia Cardiologica 2014;9(2):173-178.

Keywords

perindopril
pleiotropic effects

Authors

Maciej Krzysztof Kluk
Beata Wożakowska-Kapłon

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