open access

Vol 9, No 2 (2014)
Review Papers
Published online: 2014-06-26
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ADAMTS13 metalloprotease in the pathogenesis of thromboembolic disorders

Małgorzata Witoń, Joanna Gleńska-Olender, Iwona Gorczyca-Michta, Katarzyna Mazurek, Karolina Niebudek, Beata Wożakowska-Kapłon
Folia Cardiologica 2014;9(2):153-156.

open access

Vol 9, No 2 (2014)
Review Papers
Published online: 2014-06-26

Abstract

ADAMTS13, popularly known as von Willebrand cleavage protein, belongs to ADAMTS (A Disintegrin-like And Metalloprotease with Thrombospondin motifs) family. The clinical significance of multimeric VWF size regulation by ADAMTS13 is an example of the manifestation of VWF–ADAMTS13 axis disorders. Reduced activity of this enzyme results in the occurrence of thrombotic thrombocytopenic purpura.

Abstract

ADAMTS13, popularly known as von Willebrand cleavage protein, belongs to ADAMTS (A Disintegrin-like And Metalloprotease with Thrombospondin motifs) family. The clinical significance of multimeric VWF size regulation by ADAMTS13 is an example of the manifestation of VWF–ADAMTS13 axis disorders. Reduced activity of this enzyme results in the occurrence of thrombotic thrombocytopenic purpura.
Get Citation

Keywords

metalloprotease, ADAMTS13, von Willebrand factor

About this article
Title

ADAMTS13 metalloprotease in the pathogenesis of thromboembolic disorders

Journal

Folia Cardiologica

Issue

Vol 9, No 2 (2014)

Pages

153-156

Published online

2014-06-26

Bibliographic record

Folia Cardiologica 2014;9(2):153-156.

Keywords

metalloprotease
ADAMTS13
von Willebrand factor

Authors

Małgorzata Witoń
Joanna Gleńska-Olender
Iwona Gorczyca-Michta
Katarzyna Mazurek
Karolina Niebudek
Beata Wożakowska-Kapłon

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