Gut hormones regulating satiety: the gut&#8211;brain axis

Joanna Dytfeld; Danuta Pupek-Musialik

Vol 1, No 2 (2005)

Prace poglądowe

Published online: 2005-06-23

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Gut hormones regulating satiety: the gut–brain axis

Joanna Dytfeld, Danuta Pupek-Musialik

Endokrynol. Otył. Zab. Przem. Mat 2005;1(2):24-30.

Vol 1, No 2 (2005)

Prace poglądowe

Published online: 2005-06-23

Abstract

Obesity and associated complications represent significant public health problem. Many advances have been made in the understanding of the homeostatic system that regulates body weight. In particular, much attention is focused on feeding control by the gastrointestinal tract hormones. Most of them cause meal termination and hence are called satiety signals. This group comprises cholecystokinin, PYY, GLP-1. The single gut-derived hormone that increases appetite discovered to date is ghrelin. Currently there is no effective cure to the pandemic of obesity. Practical use of the knowledge about gut hormones may offer an effective antiobesity therapy.