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The role of adipose tissue in the endocrine system
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Abstract
Some differences are observed between visceral and subcutaneous adipose tissue secretory function as well as different liver effects. Changes in amounts of secreted adipokines are also induced by expansion or vanishing of the fat tissue. Adipokines should be analysed in relation to diabetes and metabolic syndrome, where obesity is an axial disorder. Besides, the adipose tissue is a place of steroids’ conversion and participates in precise regulation of local and general steroids’ balance. Adipose tissue was revealed a source of so called inflammatory cytokines (TNFα, IL-6, MCP-1) and factors affecting fibrinolysis and coagulation (PAI-1), despite lack of overt clinical signs of inflammation. They may play an important role in the pathogenesis of micro- and macrovascular complications, which are characteristic for metabolic syndrome and type 2 diabetes.
Abstract
Some differences are observed between visceral and subcutaneous adipose tissue secretory function as well as different liver effects. Changes in amounts of secreted adipokines are also induced by expansion or vanishing of the fat tissue. Adipokines should be analysed in relation to diabetes and metabolic syndrome, where obesity is an axial disorder. Besides, the adipose tissue is a place of steroids’ conversion and participates in precise regulation of local and general steroids’ balance. Adipose tissue was revealed a source of so called inflammatory cytokines (TNFα, IL-6, MCP-1) and factors affecting fibrinolysis and coagulation (PAI-1), despite lack of overt clinical signs of inflammation. They may play an important role in the pathogenesis of micro- and macrovascular complications, which are characteristic for metabolic syndrome and type 2 diabetes.
Keywords
adipose tissue; adipokines; steroids’ metabolism; insulin resistance; obesity


Title
The role of adipose tissue in the endocrine system
Journal
Endocrinology, Obesity and Metabolic Disorders
Issue
Pages
21-29
Published online
2005-09-26
Page views
9288
Article views/downloads
21208
Bibliographic record
Endokrynol. Otył. Zab. Przem. Mat 2005;1(3):21-29.
Keywords
adipose tissue
adipokines
steroids’ metabolism
insulin resistance
obesity
Authors
Bogda Skowrońska
Marta Fichna
Piotr Fichna