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open access

Vol 2, No 2 (2006)
Prace oryginalne
Published online: 2006-05-20
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Concentrations of soluble intercellular adhesive molucule-1 (sICAM-1) and E-selectin in patients suffering from acromegaly. Preliminary report

Marek Bolanowski, Jacek Daroszewski, Marcin Kałużny, Joanna Stankiewicz-Olczyk
Endokrynol. Otył. Zab. Przem. Mat 2006;2(2):39-42.

open access

Vol 2, No 2 (2006)
Prace oryginalne
Published online: 2006-05-20

Abstract

INTRODUCTION. Acromegaly is a rare disease caused by excessive growth hormone (GH) secretion from pituitary adenoma which is accompanied by increased morbidity and mortality due to cardiovascular diseases. Important role of endothelium dysfunction is suggested. Serum concentrations of soluble intercellular adhesive molecule-1 (sICAM-1) and E-selectin might reflect endothelial dysfunctions. The aim of the study was to assess serum concentrations of sICAM-1 and sE-selectin in patients with acromegaly in various stages of the disease.
MATERIAL AND METHODS. Serum concentrations of sICAM-1 and sE-selectin using ELISA were analyzed in 18 patients with active acromegaly and 14 ones cured from the disease.
RESULTS. No differences in sICAM-1 and sE-selectin levels between mogroups of patients studied were shown. No correlations between endothelial function markers and hormonal results (GH, IGF-1) were observed.
CONCLUSION. Serum concentrations of adhesive molecules reflecting endothelial dysfunction (sICAM-1 and sE-selectin) do not differentiate patients with active acromegaly from cured patients.

Abstract

INTRODUCTION. Acromegaly is a rare disease caused by excessive growth hormone (GH) secretion from pituitary adenoma which is accompanied by increased morbidity and mortality due to cardiovascular diseases. Important role of endothelium dysfunction is suggested. Serum concentrations of soluble intercellular adhesive molecule-1 (sICAM-1) and E-selectin might reflect endothelial dysfunctions. The aim of the study was to assess serum concentrations of sICAM-1 and sE-selectin in patients with acromegaly in various stages of the disease.
MATERIAL AND METHODS. Serum concentrations of sICAM-1 and sE-selectin using ELISA were analyzed in 18 patients with active acromegaly and 14 ones cured from the disease.
RESULTS. No differences in sICAM-1 and sE-selectin levels between mogroups of patients studied were shown. No correlations between endothelial function markers and hormonal results (GH, IGF-1) were observed.
CONCLUSION. Serum concentrations of adhesive molecules reflecting endothelial dysfunction (sICAM-1 and sE-selectin) do not differentiate patients with active acromegaly from cured patients.
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Keywords

acromegaly; sICAM-1; sE-selectin; endothelium

About this article
Title

Concentrations of soluble intercellular adhesive molucule-1 (sICAM-1) and E-selectin in patients suffering from acromegaly. Preliminary report

Journal

Endocrinology, Obesity and Metabolic Disorders

Issue

Vol 2, No 2 (2006)

Pages

39-42

Published online

2006-05-20

Page views

672

Article views/downloads

2352

Bibliographic record

Endokrynol. Otył. Zab. Przem. Mat 2006;2(2):39-42.

Keywords

acromegaly
sICAM-1
sE-selectin
endothelium

Authors

Marek Bolanowski
Jacek Daroszewski
Marcin Kałużny
Joanna Stankiewicz-Olczyk

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