Concentrations of soluble intercellular adhesive molucule-1 (sICAM-1) and E-selectin in patients suffering from acromegaly. Preliminary report

Marek Bolanowski; Jacek Daroszewski; Marcin Kałużny; Joanna Stankiewicz-Olczyk

Vol 2, No 2 (2006)

Prace oryginalne

Published online: 2006-05-20

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Concentrations of soluble intercellular adhesive molucule-1 (sICAM-1) and E-selectin in patients suffering from acromegaly. Preliminary report

Marek Bolanowski, Jacek Daroszewski, Marcin Kałużny, Joanna Stankiewicz-Olczyk

Endokrynol. Otył. Zab. Przem. Mat 2006;2(2):39-42.

Vol 2, No 2 (2006)

Prace oryginalne

Published online: 2006-05-20

Abstract

INTRODUCTION. Acromegaly is a rare disease caused by excessive growth hormone (GH) secretion from pituitary adenoma which is accompanied by increased morbidity and mortality due to cardiovascular diseases. Important role of endothelium dysfunction is suggested. Serum concentrations of soluble intercellular adhesive molecule-1 (sICAM-1) and E-selectin might reflect endothelial dysfunctions. The aim of the study was to assess serum concentrations of sICAM-1 and sE-selectin in patients with acromegaly in various stages of the disease.
MATERIAL AND METHODS. Serum concentrations of sICAM-1 and sE-selectin using ELISA were analyzed in 18 patients with active acromegaly and 14 ones cured from the disease.
RESULTS. No differences in sICAM-1 and sE-selectin levels between mogroups of patients studied were shown. No correlations between endothelial function markers and hormonal results (GH, IGF-1) were observed.
CONCLUSION. Serum concentrations of adhesive molecules reflecting endothelial dysfunction (sICAM-1 and sE-selectin) do not differentiate patients with active acromegaly from cured patients.