Genetic disorders in children with obesity

Katarzyna T. Ziora; Karol Kardas; Mateusz Kubica; Karolina N. Ziora

Vol 3, No 1 (2007)

Prace poglądowe

Published online: 2007-02-05

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Genetic disorders in children with obesity

Katarzyna T. Ziora, Karol Kardas, Mateusz Kubica, Karolina N. Ziora

Endokrynol. Otył. Zab. Przem. Mat 2007;3(1):19-28.

Vol 3, No 1 (2007)

Prace poglądowe

Published online: 2007-02-05

Abstract

Genetic syndromes with obesity in children are very rare. There is a need of genetic diagnostics in obese child when its growth is slow and it has characteristic phenotype anomalies, deficits of sight or hearing, psychomotor retardation and/or mental retardation of different degree. The knowledge of these syndromes enables to undertake early and complex therapy. Recent molecular studies reveal that such syndromes are genetically heterogenic. The aim of the paper is to present clinical and genetic aspects of the most known and the most common genetic syndromes with obesity like: Bardet-Biedl syndrome, Cohen syndrome, Alström syndrome and Prader-Willi syndrome.