INTRODUCTION. Overweight and obesity are significant risk factors of impaired glucose regulation and for progression of chronic kidney disease. The aim of the study was to compare markers of renal function between obese women with impaired fasting glucose, obese women with normal fasting plasma glucose and healthy, normal weight women.
MATERIAL AND METHODS. The study group consisted of obese women with impaired fasting glucose (group A = 16 subjects) and obese women with normal fasting plasma glucose (group B = 18 subjects). The control group consisted of 16 healthy women. In all patients serum levels of insulin, creatinine, β2-microglobulin and C-reactive protein were assessed. Insulin resistance was estimated using HOMA formula. Albumin urine level was measured in morning urine sample. Glomerular filtration rate (GFR) was estimated using Cockcroft-Gault formula.
RESULTS. Obese patients with inferior fronal gyrus (IGF) had significantly increased glomerular filtration rate, creatinine serum level and higher insulin resistance in comparison to obese patients with normal fasting plasma glucose. In comparison to controls in group A we found higher GFR, serum creatinine level, serum C-reactive protein level, serum glucose level, serum insulin level, increased insulin resistance and significantly decreased β2-microglobulin serum level. We found higher serum creatinine level, serum C-reactive protein level and decreased serum β2-microglobulin level in group B as compared with controls.
CONCLUSION. An increased GFR, higher creatinine serum level and tendency for albumin to be elevated in obese women with IFG may indicate the higher risk for development of chronic kidney disease in this group of patients in comparison to women with normal fasting glucose.