Shortcuts

open access

Vol 6, No 1 (2010)
Prace oryginalne
Published online: 2010-05-12
Get Citation

Evaluation of weight loss influence on albuminuria and glomerular filtration rate in patients with obesity

Paweł Bogdański, Monika Szulińska, Magdalena Kujawska-Łuczak, Danuta Pupek-Musialik
Endokrynol. Otył. Zab. Przem. Mat 2010;6(1):26-35.

open access

Vol 6, No 1 (2010)
Prace oryginalne
Published online: 2010-05-12

Abstract

INTRODUCTION. Over the past two decades significant increase in overweight and obesity prevalence has been observed. Growing number of evidence indicate obesity as an important risk factor in pathogenesis of chronic kidney disease. The aim of the study was to evaluate the influence of body weight reduction on creatinine clearance and concentration of albumin in urine.
MATERIAL AND METHODS. 26 patients (13 men and 13 women) with obesity were studied. Physical examination was carried out. Serum concentrations of lipids, glucose and creatinine were assessed. Creatinine clearance (GFR) was calculated using the equations of Cockroft-Gault. In the morning urine albumin concentration with use of turbidimetric method was estimated. After six-months body weight reduction program all studied parameters were again assessed.
RESULTS. Elevated concentration of urine albumin was fund. Positive correlation between glucose concentration and GFR, body mass index (BMI) and GFR, waist circumference and GFR; and glucose concentration and albumin urine concentration, waist circumference and albumin urine concentration were noticed. After six-moths reduction program BMI, waist circumference, diastolic blood pressure, GFR and albumin urine concentration decreased significantly. Positive correlations between waist circumference change and: creatinine clearance change and albumin urine concentration change were found.
CONCLUSIONS.
1. Obesity is associated with features of renal damage and body weight reduction exerts nephroprotective effect.
2. Positive body weight reduction influence relates mainly to waist circumference reduction.
3. Visceral fat tissue should be considered in the complex pathogenesis of obesity related nephropathy, what need further studies.

Abstract

INTRODUCTION. Over the past two decades significant increase in overweight and obesity prevalence has been observed. Growing number of evidence indicate obesity as an important risk factor in pathogenesis of chronic kidney disease. The aim of the study was to evaluate the influence of body weight reduction on creatinine clearance and concentration of albumin in urine.
MATERIAL AND METHODS. 26 patients (13 men and 13 women) with obesity were studied. Physical examination was carried out. Serum concentrations of lipids, glucose and creatinine were assessed. Creatinine clearance (GFR) was calculated using the equations of Cockroft-Gault. In the morning urine albumin concentration with use of turbidimetric method was estimated. After six-months body weight reduction program all studied parameters were again assessed.
RESULTS. Elevated concentration of urine albumin was fund. Positive correlation between glucose concentration and GFR, body mass index (BMI) and GFR, waist circumference and GFR; and glucose concentration and albumin urine concentration, waist circumference and albumin urine concentration were noticed. After six-moths reduction program BMI, waist circumference, diastolic blood pressure, GFR and albumin urine concentration decreased significantly. Positive correlations between waist circumference change and: creatinine clearance change and albumin urine concentration change were found.
CONCLUSIONS.
1. Obesity is associated with features of renal damage and body weight reduction exerts nephroprotective effect.
2. Positive body weight reduction influence relates mainly to waist circumference reduction.
3. Visceral fat tissue should be considered in the complex pathogenesis of obesity related nephropathy, what need further studies.
Get Citation

Keywords

obesity; microalbuminuria; glomerular filtration rate; physical activity; weight reduction

About this article
Title

Evaluation of weight loss influence on albuminuria and glomerular filtration rate in patients with obesity

Journal

Endocrinology, Obesity and Metabolic Disorders

Issue

Vol 6, No 1 (2010)

Pages

26-35

Published online

2010-05-12

Bibliographic record

Endokrynol. Otył. Zab. Przem. Mat 2010;6(1):26-35.

Keywords

obesity
microalbuminuria
glomerular filtration rate
physical activity
weight reduction

Authors

Paweł Bogdański
Monika Szulińska
Magdalena Kujawska-Łuczak
Danuta Pupek-Musialik

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

Wydawcą serwisu jest "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk,

tel. +48 58 320 94 94, faks +48 58 320 94 94, e-mail:  viamedica@viamedica.pl