INTRODUCTION. Over the past two decades significant increase in overweight and obesity prevalence has been observed. Growing number of evidence indicate obesity as an important risk factor in pathogenesis of chronic kidney disease. The aim of the study was to evaluate the influence of body weight reduction on creatinine clearance and concentration of albumin in urine.
MATERIAL AND METHODS. 26 patients (13 men and 13 women) with obesity were studied. Physical examination was carried out. Serum concentrations of lipids, glucose and creatinine were assessed. Creatinine clearance (GFR) was calculated using the equations of Cockroft-Gault. In the morning urine albumin concentration with use of turbidimetric method was estimated. After six-months body weight reduction program all studied parameters were again assessed.
RESULTS. Elevated concentration of urine albumin was fund. Positive correlation between glucose concentration and GFR, body mass index (BMI) and GFR, waist circumference and GFR; and glucose concentration and albumin urine concentration, waist circumference and albumin urine concentration were noticed. After six-moths reduction program BMI, waist circumference, diastolic blood pressure, GFR and albumin urine concentration decreased significantly. Positive correlations between waist circumference change and: creatinine clearance change and albumin urine concentration change were found.
CONCLUSIONS.
1. Obesity is associated with features of renal damage and body weight reduction exerts nephroprotective effect.
2. Positive body weight reduction influence relates mainly to waist circumference reduction.
3. Visceral fat tissue should be considered in the complex pathogenesis of obesity related nephropathy, what need further studies.