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Evaluation of weight loss influence on albuminuria and glomerular filtration rate in patients with obesity
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Abstract
MATERIAL AND METHODS. 26 patients (13 men and 13 women) with obesity were studied. Physical examination was carried out. Serum concentrations of lipids, glucose and creatinine were assessed. Creatinine clearance (GFR) was calculated using the equations of Cockroft-Gault. In the morning urine albumin concentration with use of turbidimetric method was estimated. After six-months body weight reduction program all studied parameters were again assessed.
RESULTS. Elevated concentration of urine albumin was fund. Positive correlation between glucose concentration and GFR, body mass index (BMI) and GFR, waist circumference and GFR; and glucose concentration and albumin urine concentration, waist circumference and albumin urine concentration were noticed. After six-moths reduction program BMI, waist circumference, diastolic blood pressure, GFR and albumin urine concentration decreased significantly. Positive correlations between waist circumference change and: creatinine clearance change and albumin urine concentration change were found.
CONCLUSIONS.
1. Obesity is associated with features of renal damage and body weight reduction exerts nephroprotective effect.
2. Positive body weight reduction influence relates mainly to waist circumference reduction.
3. Visceral fat tissue should be considered in the complex pathogenesis of obesity related nephropathy, what need further studies.
Abstract
MATERIAL AND METHODS. 26 patients (13 men and 13 women) with obesity were studied. Physical examination was carried out. Serum concentrations of lipids, glucose and creatinine were assessed. Creatinine clearance (GFR) was calculated using the equations of Cockroft-Gault. In the morning urine albumin concentration with use of turbidimetric method was estimated. After six-months body weight reduction program all studied parameters were again assessed.
RESULTS. Elevated concentration of urine albumin was fund. Positive correlation between glucose concentration and GFR, body mass index (BMI) and GFR, waist circumference and GFR; and glucose concentration and albumin urine concentration, waist circumference and albumin urine concentration were noticed. After six-moths reduction program BMI, waist circumference, diastolic blood pressure, GFR and albumin urine concentration decreased significantly. Positive correlations between waist circumference change and: creatinine clearance change and albumin urine concentration change were found.
CONCLUSIONS.
1. Obesity is associated with features of renal damage and body weight reduction exerts nephroprotective effect.
2. Positive body weight reduction influence relates mainly to waist circumference reduction.
3. Visceral fat tissue should be considered in the complex pathogenesis of obesity related nephropathy, what need further studies.
Keywords
obesity; microalbuminuria; glomerular filtration rate; physical activity; weight reduction
Title
Evaluation of weight loss influence on albuminuria and glomerular filtration rate in patients with obesity
Journal
Endocrinology, Obesity and Metabolic Disorders
Issue
Pages
26-35
Published online
2010-05-12
Page views
732
Article views/downloads
2987
Bibliographic record
Endokrynol. Otył. Zab. Przem. Mat 2010;6(1):26-35.
Keywords
obesity
microalbuminuria
glomerular filtration rate
physical activity
weight reduction
Authors
Paweł Bogdański
Monika Szulińska
Magdalena Kujawska-Łuczak
Danuta Pupek-Musialik