Orexins - neuropeptides with multiple actions

Aleksandra Jawiarczyk; Marek Bolanowski

Vol 6, No 3 (2010)

Prace poglądowe

Published online: 2010-12-10

View PDF (Polish)

Download PDF file

Get Citation

Orexins - neuropeptides with multiple actions

Aleksandra Jawiarczyk, Marek Bolanowski

Endokrynol. Otył. Zab. Przem. Mat 2010;6(3):147-153.

Vol 6, No 3 (2010)

Prace poglądowe

Published online: 2010-12-10

Abstract

Orexins (hypocretins) are two neuropeptides originating from the same precursor, preprohypocretin. They are situated mainly in the hypothalamus, while orexin fibres project throughout the brain. Orexins action is mediated via G-protein coupled receptors of two different subtypes (OxR1 and OxR2). These neuropeptides are responsible for control of food intake, energy expenditure as well as the regulation of pituitary hormone secretion and sleep-wake function. The recent studies show the significant influence of these neuropeptides for the organism, including orexin’s role in drugs addiction. Further investigation into orexin system may create new therapeutic options for curing the diseases such as narcolepsy, disturbance in secretion of growth hormone or drug abuse. Endocrinology, Obesity and Metabolic Disorders 2010, vol. 6, No 3, 147-153