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Vol 6, No 3 (2010)
Prace poglądowe
Published online: 2010-12-10
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The role of glucagon in the pathogenesis of type 2 diabetes

Marcin Nylec, Magdalena Olszanecka-Glinianowicz
Endokrynol. Otył. Zab. Przem. Mat 2010;6(3):136-140.

open access

Vol 6, No 3 (2010)
Prace poglądowe
Published online: 2010-12-10

Abstract

Type 2 diabetes is a metabolic disease caused by the resistance of peripheral tissues to insulin action. Currently of the role of metabolically active agents secreted by adipose tissue (adipokines) in the development of insulin resistance of adipose tissue, myocytes and hepatocytes is growing is known initially in the course of type 2 diabetes the insulin resistance is compensated by hyperinsulinaemia, however a gradual involution of beta-cells in the pancreas with some contribution of adipokines, followed by the decrease of their number is leading to the appearance of type 2 diabetes. Impaired postprandial secretion of insulin is related to the abnormal function of incretin system (decreased secretion of glucagon like peptide-1). Although the participation of glucagon a main insulin antagonist is hardly comprehensible. The aim of this review is to summarize the current knowledge concerning the role of glucagon in the development of impaired carbohydrate tolerance and type 2 diabetes.
Endocrinology, Obesity and Metabolic Disorders 2010, vol. 6, No 3, 136-140

Abstract

Type 2 diabetes is a metabolic disease caused by the resistance of peripheral tissues to insulin action. Currently of the role of metabolically active agents secreted by adipose tissue (adipokines) in the development of insulin resistance of adipose tissue, myocytes and hepatocytes is growing is known initially in the course of type 2 diabetes the insulin resistance is compensated by hyperinsulinaemia, however a gradual involution of beta-cells in the pancreas with some contribution of adipokines, followed by the decrease of their number is leading to the appearance of type 2 diabetes. Impaired postprandial secretion of insulin is related to the abnormal function of incretin system (decreased secretion of glucagon like peptide-1). Although the participation of glucagon a main insulin antagonist is hardly comprehensible. The aim of this review is to summarize the current knowledge concerning the role of glucagon in the development of impaired carbohydrate tolerance and type 2 diabetes.
Endocrinology, Obesity and Metabolic Disorders 2010, vol. 6, No 3, 136-140
Get Citation

Keywords

glucagon; insulin; pathogenesis; type 2 diabetes

About this article
Title

The role of glucagon in the pathogenesis of type 2 diabetes

Journal

Endocrinology, Obesity and Metabolic Disorders

Issue

Vol 6, No 3 (2010)

Pages

136-140

Published online

2010-12-10

Page views

1079

Article views/downloads

8656

Bibliographic record

Endokrynol. Otył. Zab. Przem. Mat 2010;6(3):136-140.

Keywords

glucagon
insulin
pathogenesis
type 2 diabetes

Authors

Marcin Nylec
Magdalena Olszanecka-Glinianowicz

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