The role of glucagon in the pathogenesis of type 2 diabetes

Marcin Nylec; Magdalena Olszanecka-Glinianowicz

Vol 6, No 3 (2010)

Prace poglądowe

Published online: 2010-12-10

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The role of glucagon in the pathogenesis of type 2 diabetes

Marcin Nylec, Magdalena Olszanecka-Glinianowicz

Endokrynol. Otył. Zab. Przem. Mat 2010;6(3):136-140.

Vol 6, No 3 (2010)

Prace poglądowe

Published online: 2010-12-10

Abstract

Type 2 diabetes is a metabolic disease caused by the resistance of peripheral tissues to insulin action. Currently of the role of metabolically active agents secreted by adipose tissue (adipokines) in the development of insulin resistance of adipose tissue, myocytes and hepatocytes is growing is known initially in the course of type 2 diabetes the insulin resistance is compensated by hyperinsulinaemia, however a gradual involution of beta-cells in the pancreas with some contribution of adipokines, followed by the decrease of their number is leading to the appearance of type 2 diabetes. Impaired postprandial secretion of insulin is related to the abnormal function of incretin system (decreased secretion of glucagon like peptide-1). Although the participation of glucagon a main insulin antagonist is hardly comprehensible. The aim of this review is to summarize the current knowledge concerning the role of glucagon in the development of impaired carbohydrate tolerance and type 2 diabetes.
Endocrinology, Obesity and Metabolic Disorders 2010, vol. 6, No 3, 136-140