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Hyperhomocysteinaemia in patients with primary hypertension
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Abstract
MATERIAL AND METHODS. The study included 50 patients with primary hypertension aged 19–65 years without co-morbidities or complications. The control group consisted of 42 healthy volunteers aged 24–59 years. The levels of homocysteine were determined by fluorescence polarisation immunoassay (FPIA), those of folic acid by microparticle enzyme immunoassay (MEIA) and those of cystatin C by nephelometry (Nephelometer Analyzer II). Statistical analysis was performed using Statistica v. 9.0.
RESULTS. The study showed a higher prevalence of hyperhomocysteinaemia in patients with primary hypertension than in healthy individuals and higher homocysteine levels in men than in women. Hyperhomocysteinaemia was also shown to occur more commonly in patients with primary hypertension aged 50 years of more. Increased serum homocysteine was accompanied by higher levels of cystatin C. There was a positive correlation between homocysteine levels and age and cystatin C levels in patients with primary hypertension.
CONCLUSIONS. Based on our study it may be concluded that the elevation in homocysteine level in patients with primary hypertension is not only caused by folic acid deficiency but is also associated with reduced glomerular filtration.
Endocrinology, Obesity and Metabolic Disorders 2011, vol. 7, No 1, 1–10
Abstract
MATERIAL AND METHODS. The study included 50 patients with primary hypertension aged 19–65 years without co-morbidities or complications. The control group consisted of 42 healthy volunteers aged 24–59 years. The levels of homocysteine were determined by fluorescence polarisation immunoassay (FPIA), those of folic acid by microparticle enzyme immunoassay (MEIA) and those of cystatin C by nephelometry (Nephelometer Analyzer II). Statistical analysis was performed using Statistica v. 9.0.
RESULTS. The study showed a higher prevalence of hyperhomocysteinaemia in patients with primary hypertension than in healthy individuals and higher homocysteine levels in men than in women. Hyperhomocysteinaemia was also shown to occur more commonly in patients with primary hypertension aged 50 years of more. Increased serum homocysteine was accompanied by higher levels of cystatin C. There was a positive correlation between homocysteine levels and age and cystatin C levels in patients with primary hypertension.
CONCLUSIONS. Based on our study it may be concluded that the elevation in homocysteine level in patients with primary hypertension is not only caused by folic acid deficiency but is also associated with reduced glomerular filtration.
Endocrinology, Obesity and Metabolic Disorders 2011, vol. 7, No 1, 1–10
Keywords
hypertension; homocysteine; folic acid; cystatin C
Title
Hyperhomocysteinaemia in patients with primary hypertension
Journal
Endocrinology, Obesity and Metabolic Disorders
Issue
Pages
1-10
Published online
2011-06-17
Page views
890
Article views/downloads
3715
Bibliographic record
Endokrynol. Otył. Zab. Przem. Mat 2011;7(1):1-10.
Keywords
hypertension
homocysteine
folic acid
cystatin C
Authors
Aleksandra Baszczuk
Zygmunt Kopczyński
Danuta Pupek-Musialik
Maciej Cymerys
Jarosław Kopczyński
Joanna Wojtkowiak