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Vol 7, No 4 (2011)
Prace oryginalne
Published online: 2012-02-22
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Circadian concentrations of DHEA and bone status in postmenopausal obese women

Zofia Ostrowska, Beata Kos-Kudła, Bogdan Marek, Dariusz Kajdaniuk, Bożena Szapska, Kinga Wołkowska-Pokrywa
Endokrynol. Otył. Zab. Przem. Mat 2011;7(4):197-207.

open access

Vol 7, No 4 (2011)
Prace oryginalne
Published online: 2012-02-22

Abstract


INTRODUCTION. It has been suggested that increased DHEA secretion in postmenopausal obese women might affect bone tissue; the association might be significantly influenced by OPG and its ligand, RANKL. The aim of the study was to determine whether postmenopausal obese women showed any relationship between circadian concentrations of DHEA and BMD and bone metabolism, and to establish whether OPG and RANKL might play a role in the relationship.
MATERIAL AND METHODS. Thirty-five postmenopausal women (20 obese and 15 healthy individuals) underwent BMD of the lumbar spine (L2–L4) by dual-energy X-ray absorptiometry (DXA); serum DHEA, bone markers (OC and CTx), OPG and its soluble ligand sRANKL levels were determined by ELISA in serum samples collected every three hours.
RESULTS. A significant increase in body mass, BMI and WHR indices and BMD in obese women was accompanied by a significant increase of mean circadian concentration of DHEA, and a decrease of mean circadian concentrations of OC, CTx, OPG, and sRANKL. The amplitudes of OC, CTx, OPG and sRANKL rhythms were also decreased, and a shift was observed in sRANKL rhythm acrophase. Positive correlations were revealed between BMD and DHEA and OPG/sRANKL ratio. A negative correlation was found between BMD and sRANKL. Circadian concentrations of DHEA were negatively correlated with OC, CTx and sRANKL and positively with OPG and OPG/sRANKL ratio. A negative correlation was seen between circadian concentrations of sRANKL and OC and OPG.
CONCLUSIONS. Postmenopausal obesity results in elevation of circadian DHEA secretion associated with increased BMD, decreased bone metabolism, and suppression of circadian OPG and sRANKL oscillations. Increased DHEA secretion in postmenopausal obese women may beneficially affect bone tissue most probably via a shift in the OPG/RANKL ratio that tilts the balance toward a functional excess of OPG.

Abstract


INTRODUCTION. It has been suggested that increased DHEA secretion in postmenopausal obese women might affect bone tissue; the association might be significantly influenced by OPG and its ligand, RANKL. The aim of the study was to determine whether postmenopausal obese women showed any relationship between circadian concentrations of DHEA and BMD and bone metabolism, and to establish whether OPG and RANKL might play a role in the relationship.
MATERIAL AND METHODS. Thirty-five postmenopausal women (20 obese and 15 healthy individuals) underwent BMD of the lumbar spine (L2–L4) by dual-energy X-ray absorptiometry (DXA); serum DHEA, bone markers (OC and CTx), OPG and its soluble ligand sRANKL levels were determined by ELISA in serum samples collected every three hours.
RESULTS. A significant increase in body mass, BMI and WHR indices and BMD in obese women was accompanied by a significant increase of mean circadian concentration of DHEA, and a decrease of mean circadian concentrations of OC, CTx, OPG, and sRANKL. The amplitudes of OC, CTx, OPG and sRANKL rhythms were also decreased, and a shift was observed in sRANKL rhythm acrophase. Positive correlations were revealed between BMD and DHEA and OPG/sRANKL ratio. A negative correlation was found between BMD and sRANKL. Circadian concentrations of DHEA were negatively correlated with OC, CTx and sRANKL and positively with OPG and OPG/sRANKL ratio. A negative correlation was seen between circadian concentrations of sRANKL and OC and OPG.
CONCLUSIONS. Postmenopausal obesity results in elevation of circadian DHEA secretion associated with increased BMD, decreased bone metabolism, and suppression of circadian OPG and sRANKL oscillations. Increased DHEA secretion in postmenopausal obese women may beneficially affect bone tissue most probably via a shift in the OPG/RANKL ratio that tilts the balance toward a functional excess of OPG.
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Keywords

DHEA; BMD; OPG; sRANKL; obese women; menopause

About this article
Title

Circadian concentrations of DHEA and bone status in postmenopausal obese women

Journal

Endocrinology, Obesity and Metabolic Disorders

Issue

Vol 7, No 4 (2011)

Pages

197-207

Published online

2012-02-22

Bibliographic record

Endokrynol. Otył. Zab. Przem. Mat 2011;7(4):197-207.

Keywords

DHEA
BMD
OPG
sRANKL
obese women
menopause

Authors

Zofia Ostrowska
Beata Kos-Kudła
Bogdan Marek
Dariusz Kajdaniuk
Bożena Szapska
Kinga Wołkowska-Pokrywa

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