Evaluation of plasminogen activator inhibitor 1 concentration in patients with simple obesity

Paweł Bogdański; Monika Szulińska; Joanna Dytfeld; Danuta Pupek-Musialik

Vol 8, No 1 (2012)

Prace oryginalne

Published online: 2012-04-26

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Evaluation of plasminogen activator inhibitor 1 concentration in patients with simple obesity

Paweł Bogdański, Monika Szulińska, Joanna Dytfeld, Danuta Pupek-Musialik

Endokrynol. Otył. Zab. Przem. Mat 2012;8(1):1-7.

Vol 8, No 1 (2012)

Prace oryginalne

Published online: 2012-04-26

Abstract

INTRODUCTION. Relationship between obesity and atherosclerosis development is well-documented. Among risk factors of atherosclerosis progression are both „old” and „new” — which clinical value is still intensively studied. In the pathogenesis of increased procoagulat state observed in obese patients potential role of plasminogen activator inhibitor 1 (PAI-1) is analysed. The aim of the study was to evaluate PAI-1 concentration and its relationship with selected anthropometric and biochemical parameters.
MATERIAL AND METHODS. 88 obese patients and 25 healthy subjects as a control were studied. Anthropometric parameters, concentrations of: fasting glucose, lipids, insulin with use of radioimmunomethric method, tumor necrosis factor alpha (TNFa) and PAI-1 with use of immunoenzymatic method were assessed. Insulin resistance in the participants was evaluated according to the homeostasis model assessment–insulin resistance (HOMA-IR) protocol.
RESULTS. Serum concentrations TNFa, PAI-1 and HOMA-IR index were significantly higher in the studied group as compared to the control. Positive correlation between insulin concentration, HOMA-IR and PAI-1 were found.
CONCLUSIONS. 1. Obese patients characterise increased activation of inflammatory process, procoagulant predisposition and insulin resistance. 2. In the pathogenesis of increased procoagulant activity in obese patients, observed in our study as elevated PAI-1 concentration, insulin resistance role should be considered.