open access
Evaluation of plasminogen activator inhibitor 1 concentration in patients with simple obesity
open access
Abstract
MATERIAL AND METHODS. 88 obese patients and 25 healthy subjects as a control were studied. Anthropometric parameters, concentrations of: fasting glucose, lipids, insulin with use of radioimmunomethric method, tumor necrosis factor alpha (TNFa) and PAI-1 with use of immunoenzymatic method were assessed. Insulin resistance in the participants was evaluated according to the homeostasis model assessment–insulin resistance (HOMA-IR) protocol.
RESULTS. Serum concentrations TNFa, PAI-1 and HOMA-IR index were significantly higher in the studied group as compared to the control. Positive correlation between insulin concentration, HOMA-IR and PAI-1 were found.
CONCLUSIONS. 1. Obese patients characterise increased activation of inflammatory process, procoagulant predisposition and insulin resistance. 2. In the pathogenesis of increased procoagulant activity in obese patients, observed in our study as elevated PAI-1 concentration, insulin resistance role should be considered.
Abstract
MATERIAL AND METHODS. 88 obese patients and 25 healthy subjects as a control were studied. Anthropometric parameters, concentrations of: fasting glucose, lipids, insulin with use of radioimmunomethric method, tumor necrosis factor alpha (TNFa) and PAI-1 with use of immunoenzymatic method were assessed. Insulin resistance in the participants was evaluated according to the homeostasis model assessment–insulin resistance (HOMA-IR) protocol.
RESULTS. Serum concentrations TNFa, PAI-1 and HOMA-IR index were significantly higher in the studied group as compared to the control. Positive correlation between insulin concentration, HOMA-IR and PAI-1 were found.
CONCLUSIONS. 1. Obese patients characterise increased activation of inflammatory process, procoagulant predisposition and insulin resistance. 2. In the pathogenesis of increased procoagulant activity in obese patients, observed in our study as elevated PAI-1 concentration, insulin resistance role should be considered.
Keywords
otyłość; inhibitor tkankowego aktywatora plazminogenu 1; insulinooporność; proces zapalny
Title
Evaluation of plasminogen activator inhibitor 1 concentration in patients with simple obesity
Journal
Endocrinology, Obesity and Metabolic Disorders
Issue
Pages
1-7
Published online
2012-04-26
Page views
717
Article views/downloads
4930
Bibliographic record
Endokrynol. Otył. Zab. Przem. Mat 2012;8(1):1-7.
Keywords
otyłość
inhibitor tkankowego aktywatora plazminogenu 1
insulinooporność
proces zapalny
Authors
Paweł Bogdański
Monika Szulińska
Joanna Dytfeld
Danuta Pupek-Musialik