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Evaluation of pulmonary side effects in prolactinoma patients treated with cabergoline
, 2, 3, 3, 4, 1
Affiliations- Division of Endocrinology and Metabolism, Department of Internal Medicine, Istanbul Medical Faculty, Istanbul University, Istanbul, Türkiye
- Department of Pulmonary Diseases, Istanbul Medical Faculty, Istanbul University, Istanbul, Türkiye
- Division of Endocrinology and Metabolism, Department of Internal Medicine, Bakırkoy Dr. Sadi Konuk Research and Training Hospital, Istanbul, Türkiye
- Division of Endocrinology and Metabolism, Department of Internal Medicine, Maslak Hospital, Acibadem University, Istanbul, Türkiye
open access
Abstract
Introduction: Cabergoline (CAB) is the most used dopamine agonist in the treatment of prolactinomas. Studies related to the treatment of Parkinson’s disease have shown that dopamine agonists can lead to fibrotic syndromes affecting the heart and the lung.
The aim of this study was to evaluate the possible pulmonary side effects of CAB in prolactinoma patients.
Material and methods: Chest X-ray imaging and pulmonary function parameters like forced vital capacity (FVC), total lung capacity (TLC), and diffusion capacity for carbon monoxide (DLCO) were evaluated in 73 prolactinoma patients. The cumulative dose of CAB and the total duration of CAB use were also calculated, and all data were reviewed retrospectively.
Results: The median cumulative CAB dose was 192 mg, and the median duration of CAB use was 64 months. Only 13 patients (17%) among this cohort had abnormal DLCO results that could be an indirect sign of pulmonary fibrosis. These abnormal DLCO results were found not to be associated with cumulative CAB dose in these 13 patients.
Conclusions: CAB appears to be safe in terms of pulmonary functions with a median cumulative dose of 192 mg in prolactinoma patients.
Abstract
Introduction: Cabergoline (CAB) is the most used dopamine agonist in the treatment of prolactinomas. Studies related to the treatment of Parkinson’s disease have shown that dopamine agonists can lead to fibrotic syndromes affecting the heart and the lung.
The aim of this study was to evaluate the possible pulmonary side effects of CAB in prolactinoma patients.
Material and methods: Chest X-ray imaging and pulmonary function parameters like forced vital capacity (FVC), total lung capacity (TLC), and diffusion capacity for carbon monoxide (DLCO) were evaluated in 73 prolactinoma patients. The cumulative dose of CAB and the total duration of CAB use were also calculated, and all data were reviewed retrospectively.
Results: The median cumulative CAB dose was 192 mg, and the median duration of CAB use was 64 months. Only 13 patients (17%) among this cohort had abnormal DLCO results that could be an indirect sign of pulmonary fibrosis. These abnormal DLCO results were found not to be associated with cumulative CAB dose in these 13 patients.
Conclusions: CAB appears to be safe in terms of pulmonary functions with a median cumulative dose of 192 mg in prolactinoma patients.
Keywords
pleural fibrosis; pulmonary fibrosis; dopamine agonist; prolactinoma; cabergoline
About this articleTitle
Evaluation of pulmonary side effects in prolactinoma patients treated with cabergoline
Journal
Issue
Article type
Original paper
Pages
380-384
Published online
2023-07-18
Page views
1060
Article views/downloads
323
DOI
Pubmed
Bibliographic record
Endokrynol Pol 2023;74(4):380-384.
Keywords
pleural fibrosis
pulmonary fibrosis
dopamine agonist
prolactinoma
cabergoline
Authors
Ozlem Soyluk
Zuleyha Bingol
Sema Ciftci
Neslihan Kurtulmus
Seher Tanrikulu
Sema Yarman
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