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Serum IL-38 levels in patients with type 2 diabetes mellitus
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Affiliations- Department of Endocrinology, The Affiliated Hospital of Medical School, Ningbo University, Ningbo, China
- Department of Immunology, Zhejiang Key Laboratory of Pathophysiology, Ningbo University School of Medicine, Ningbo, China
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Abstract
Introduction: Interleukin 38 (IL-38) is a new member of the IL-1 family, and it has anti-inflammatory activity. However, its role in type 2 diabetes mellitus (T2DM) has not been reported.
Material and methods: The study included 40 T2DM patients and 42 healthy control subjects. The anthropometric and biochemical measurements were performed using an automatic biochemical analyser, high-performance liquid chromatography, and electrochemiluminescence immunoassay. Circulating IL-38 levels were determined by enzyme-linked immunosorbent assay.
Results: Serum IL-38 levels in T2DM patients were significantly lower than those in controls. Correlation analysis showed that serum IL-38 was negatively correlated with systolic blood pressure and interleukin 17 (IL-17).
Conclusions: The results suggest that IL-38 may be a new biomarker of T2DM.
Abstract
Introduction: Interleukin 38 (IL-38) is a new member of the IL-1 family, and it has anti-inflammatory activity. However, its role in type 2 diabetes mellitus (T2DM) has not been reported.
Material and methods: The study included 40 T2DM patients and 42 healthy control subjects. The anthropometric and biochemical measurements were performed using an automatic biochemical analyser, high-performance liquid chromatography, and electrochemiluminescence immunoassay. Circulating IL-38 levels were determined by enzyme-linked immunosorbent assay.
Results: Serum IL-38 levels in T2DM patients were significantly lower than those in controls. Correlation analysis showed that serum IL-38 was negatively correlated with systolic blood pressure and interleukin 17 (IL-17).
Conclusions: The results suggest that IL-38 may be a new biomarker of T2DM.
Keywords
type 2 diabetes mellitus; interleukin 38; interleukin 17
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About this articleTitle
Serum IL-38 levels in patients with type 2 diabetes mellitus
Journal
Issue
Article type
Brief communication
Pages
988-989
Published online
2022-12-12
Page views
3517
Article views/downloads
380
DOI
Pubmed
Bibliographic record
Endokrynol Pol 2022;73(6):988-989.
Keywords
type 2 diabetes mellitus
interleukin 38
interleukin 17
Authors
Tingqi Zhao
Mengxi Yu
Mingcai Li
Yan Li
