Vol 73, No 1 (2022)
Original paper
Published online: 2022-01-31

open access

Page views 6023
Article views/downloads 878
Get Citation

Connect on Social Media

Connect on Social Media

The influence of resistance training on muscle strength, irisin concentration, and metabolic parameters in type 1 diabetic patients

Marta Wróbel1, Artur Gołaś2, Dominika Rokicka1, Łukasz Pyka3, Marta Szewczyk4, Tomasz Stołtny5, Robert Roczniok2, Mariusz Gąsior3, Krzysztof Strojek1
Pubmed: 35119090
Endokrynol Pol 2022;73(1):96-102.

Abstract

Introduction: Resistance effort has a beneficial effect on muscle mass, body composition, bone density, and cardiac parameters. It is also a modulator of the inflammatory reaction. The aim of the study was to assess the impact of 3 months of resistance training on muscle strength, irisin levels, and metabolic parameters in patients with long-term type 1 diabetes.

Material and methods: Eleven type 1 male diabetic patients with low levels of physical activity were recruited, with mean age 38 ± 6 years, body mass index (BMI) 28.4 ± 2.6 kg/m2, and diabetes duration 23 ± 7 years. All subjects participated in 60-minute resistance training sessions twice a week, for three months. At baseline and after 3 months in all patients, maximal muscle strength level, serum irisin concentration, metabolic control parameters, and anthropometric measures were assessed.

Results: After 3 months there was a statistically significant increase of maximal muscle strength in comparison to baseline. There was no significant change in serum irisin concentration, HbA1c, or other assessed parameters.

Conclusion: A 3-month resistance training programme in patients with long-term type 1 diabetes and low level of physical activity significantly affects their maximum strength level. This indicates that people with diabetes are more adaptive to additional loads, which allows them to increase their load faster. 

Article available in PDF format

View PDF Download PDF file

References

  1. American Diabetes Association. Standards of Medical Care in Diabetes — 2020. Diab. Care. 2020; 43(Suppl 1): 48–65.
  2. Frayn KN, Karpe F, Funada Ji, et al. Subcutaneous adipose tissue blood flow varies between superior and inferior levels of the anterior abdominal wall. Int J Obes Relat Metab Disord. 2004; 28(2): 228–233.
  3. Riddell MC, Gallen IW, Smart CE, et al. Exercise management in type 1 diabetes: a consensus statement. Lancet Diabetes Endocrinol. 2017; 5(5): 377–390.
  4. Garber CE, Blissmer B, Deschenes MR, et al. American College of Sports Medicine. American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Med Sci Sports Exerc. 2011; 43(7): 1334–1359.
  5. Quirk H, Blake H, Tennyson R, et al. Physical activity interventions in children and young people with Type 1 diabetes mellitus: a systematic review with meta-analysis. Diabet Med. 2014; 31(10): 1163–1173.
  6. Laaksonen DE, Atalay M, Niskanen LK, et al. Aerobic exercise and the lipid profile in type 1 diabetic men: a randomized controlled trial. Med Sci Sports Exerc. 2000; 32(9): 1541–1548.
  7. Landt KW, Campaigne BN, James FW, et al. Effects of exercise training on insulin sensitivity in adolescents with type I diabetes. Diabetes Care. 1985; 8(5): 461–465.
  8. Yardley JE, Kenny GP, Perkins BA, et al. Effects of performing resistance exercise before versus after aerobic exercise on glycemia in type 1 diabetes. Diabetes Care. 2012; 35(4): 669–675.
  9. Yardley JE, Kenny GP, Perkins BA, et al. Effects of performing resistance exercise before versus after aerobic exercise on glycemia in type 1 diabetes. Diabetes Care. 2012; 35(4): 669–675.
  10. Gleeson M, Bishop NC, Stensel DJ, et al. The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease. Nat Rev Immunol. 2011; 11(9): 607–615.
  11. Aydin S, Kuloglu T, Aydin S, et al. A comprehensive immunohistochemical examination of the distribution of the fat-burning protein irisin in biological tissues. Peptides. 2014; 61: 130–136.
  12. Rabiee F, Lachinani L, Ghaedi S, et al. New insights into the cellular activities of Fndc5/Irisin and its signaling pathways. Cell Biosci. 2020; 10: 51.
  13. Enerbäck S. Human brown adipose tissue. Cell Metab. 2010; 11(4): 248–252.
  14. Mo Li, Shen J, Liu Q, et al. Irisin Is Regulated by CAR in Liver and Is a Mediator of Hepatic Glucose and Lipid Metabolism. Mol Endocrinol. 2016; 30(5): 533–542.
  15. Natalicchio A, Marrano N, Biondi G, et al. The Myokine Irisin Is Released in Response to Saturated Fatty Acids and Promotes Pancreatic β-Cell Survival and Insulin Secretion. Diabetes. 2017; 66(11): 2849–2856.
  16. Colaianni G, Cuscito C, Mongelli T, et al. The myokine irisin increases cortical bone mass. Proc Natl Acad Sci U S A. 2015; 112(39): 12157–12162.
  17. Mahgoub MO, D'Souza C, Al Darmaki RS, et al. An update on the role of irisin in the regulation of endocrine and metabolic functions. Peptides. 2018; 104: 15–23.
  18. Gołaś A, Maszczyk A, Pietraszewski P, et al. Effects of Pre-exhaustion on the Patterns of Muscular Activity in the Flat Bench Press. J Strength Cond Res. 2017; 31(7): 1919–1924.
  19. Baechle TR, Earle RW. Essential of strength training and conditioning. Human Kinetics, Champaing 2008.
  20. Stastny P, Gołaś A, Blazek D, et al. A systematic review of surface electromyography analyses of the bench press movement task. PLoS One. 2017; 12(2): e0171632.
  21. Aaberg E. Muscle mechanics. 2nd ed. Human Kinetics, Library of Congress Cataloging-in-Publication Data, Champaign 2016: Second.
  22. Flanagan SD, Mills MD, Sterczala AJ, et al. The relationship between muscle action and repetition maximum on the squat and bench press in men and women. J Strength Cond Res. 2014; 28(9): 2437–2442.
  23. Fleck SJ, Kreamer WJ. Designing Resistance Training Programs. 4th ed. Human Kinetics, Champaign 2014.
  24. Holt RIG, Sönksen PH. Growth hormone, IGF-I and insulin and their abuse in sport. Br J Pharmacol. 2008; 154(3): 542–556.
  25. Kahn CR, Weir GC, King GL. Joslin’s Diabetes Mellitus. 14th ed. Lippincott Williams and Wilkins, Philadelphia 2007: 649–657.
  26. Fink J, Schoenfeld BJ, Nakazato K. The role of hormones in muscle hypertrophy. Phys Sportsmed. 2018; 46(1): 129–134.
  27. Hwang JH, Perseghin G, Rothman DL, et al. Impaired net hepatic glycogen synthesis in insulin-dependent diabetic subjects during mixed meal ingestion. A 13C nuclear magnetic resonance spectroscopy study. J Clin Invest. 1995; 95(2): 783–787.
  28. Bally L, Buehler T, Dokumaci AS, et al. Hepatic and intramyocellular glycogen stores in adults with type 1 diabetes and healthy controls. Diabetes Res Clin Pract. 2015; 109(1): e1–e3.
  29. Bohn B, Herbst A, Pfeifer M, et al. DPV Initiative. Impact of Physical Activity on Glycemic Control and Prevalence of Cardiovascular Risk Factors in Adults With Type 1 Diabetes: A Cross-sectional Multicenter Study of 18,028 Patients. Diabetes Care. 2015; 38(8): 1536–1543.
  30. Faienza MF, Brunetti G, Sanesi L, et al. High irisin levels are associated with better glycemic control and bone health in children with Type 1 diabetes. Diabetes Res Clin Pract. 2018; 141: 10–17.
  31. Ates I, Arikan MF, Erdogan K, et al. Factors associated with increased irisin levels in the type 1 diabetes mellitus. Endocr Regul. 2017; 51(1): 1–7.
  32. Espes D, Lau J, Carlsson PO. Increased levels of irisin in people with long-standing Type 1 diabetes. Diabet Med. 2015; 32(9): 1172–1176.
  33. Tentolouris A, Eleftheriadou I, Tsilingiris D, et al. Plasma Irisin Levels in Subjects with Type 1 Diabetes: Comparison with Healthy Controls. Horm Metab Res. 2018; 50(11): 803–810.
  34. Morelli C, Avolio E, Galluccio A, et al. Impact of Vigorous-Intensity Physical Activity on Body Composition Parameters, Lipid Profile Markers, and Irisin Levels in Adolescents: A Cross-Sectional Study. Nutrients. 2020; 12(3).
  35. Nygaard H, Slettaløkken G, Vegge G, et al. Irisin in blood increases transiently after single sessions of intense endurance exercise and heavy strength training. PLoS One. 2015; 10(3): e0121367.
  36. Peterson JM, Mart R, Bond CE. Effect of obesity and exercise on the expression of the novel myokines, Myonectin and Fibronectin type III domain containing 5. PeerJ. 2014; 2: e605.